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Spatial Metabolomics Identifies LPC(18:0) and LPA(18:1) in Advanced Atheroma With Translation to Plasma for Cardiovascular Risk Estimation.
Arterioscler Thromb Vasc Biol
March 2024
Immunology Department, IIS-Fundación Jiménez Díaz-UAM, Madrid, Spain (M.M.-L., G.A.-L.).
Background: The metabolic alterations occurring within the arterial architecture during atherosclerosis development remain poorly understood, let alone those particular to each arterial tunica. We aimed first to identify, in a spatially resolved manner, the specific metabolic changes in plaque, media, adventitia, and cardiac tissue between control and atherosclerotic murine aortas. Second, we assessed their translatability to human tissue and plasma for cardiovascular risk estimation.
View Article and Find Full Text PDFNovel insights into molecular and immune subtypes of biliary tract cancers.
Adv Cancer Res
August 2022
Division of Liver Diseases, Liver Cancer Program, Department of Medicine, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States. Electronic address:
Biliary tract cancers (BTCs), which include cholangiocarcinoma (CCA) and gallbladder cancer (GBC), are heterogenous malignancies characterized by distinct molecular features often associated with specific clinical traits and/or outcomes. Such complex molecular heterogeneity, both within each BTC subtype and between distinct subtypes, poses a great challenge to personalized medicine. Recent technological advances have allowed the integration of multiple -omics derived from large cohorts of patients with distinct solid cancers to ultimately design stratification algorithms for prognostic prediction or more efficient treatment allocation.
View Article and Find Full Text PDFSpatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-tune Virtual Microdissection.
J Vis Exp
July 2022
Department of Pathology, Genentech.
Multiplexing enables the assessment of several markers on the same tissue while providing spatial context. Spatial Omics technologies allow both protein and RNA multiplexing by leveraging photo-cleavable oligo-tagged antibodies and probes, respectively. Oligos are cleaved and quantified from specific regions across the tissue to elucidate the underlying biology.
View Article and Find Full Text PDFThe contribution of neuropathology to multiple sclerosis research.
Eur J Neurol
September 2022
Center for Brain Research, Medical University of Vienna, Wien, Austria.
Background And Purpose: Neuropathology plays a major role in deciphering disease mechanisms in multiple sclerosis (MS). This review article describes recent advances in neuropathological research related to inflammatory demyelinating diseases.
Methods: A retrospective review of neuropathological studies published during the last two decades was conducted.
Microdissection of the Bulk Transcriptome at Single-Cell Resolution Reveals Clinical Significance and Myeloid Cells Heterogeneity in Lung Adenocarcinoma.
Front Immunol
December 2021
Department of Human Genetics, Department of Ultrasound and Women's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Background: Tumor infiltrating myeloid (TIM) cells constitute a vital element of the tumor microenvironment. The cell-type heterogeneity of TIM has yet to be fully investigated.
Methods: We used a time saving approach to generate a single-cell reference matrix, allowing quantification of cell-type proportions and cell-type-specific gene abundances in bulk RNA-seq data.
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