The chemical profile, cytotoxic and apoptotic effect, and antioxidant activity were determined of ethanolic extracts of Vitex agnus-castus L. (chaste tree). Ripened fruits and fruitless aerial parts were extracted with ethanol, and the chemical characterization of the extracts was determined by LC/ESI-MS-MS. Twelve compounds were tentatively identified in the extracts. The dose-dependent cytotoxic effects of the extracts were tested on C6, A549 and MCF-7 cells by using MT7 assay; inhibition of DNA synthesis, and apoptotic and caspase-3 activation effects of the extracts were determined. The potential antioxidant activities of the extracts were evaluated by in vitro methods such as DPPH and ABTS scavenging activity, reducing power and 3-carotene bleaching assays. The fruit extract showed noticeable cytotoxic activity against MCF-7 cells with an IC(50) value of 88 μg/mL. Both extracts showed similar DPPH scavenging activity comparably with that of the standard.
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