Endocytosis at the blood-brain barrier as a function for sleep.

Elife

Neuroscience Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.

Published: November 2018

Glia are important modulators of neural activity, yet few studies link glia to sleep regulation. We find that blocking activity of the endocytosis protein, dynamin, in adult glia increases sleep and enhances sleep need, manifest as resistance to sleep deprivation. Surface glia comprising the fly equivalent of the blood-brain barrier (BBB) mediate the effect of dynamin on sleep. Blocking dynamin in the surface glia causes ultrastructural changes, albeit without compromising the integrity of the barrier. Supporting a role for endocytic trafficking in sleep, a screen of Rab GTPases identifies sleep-modulating effects of the recycling endosome Rab11 in surface glia. We also find that endocytosis is increased in BBB glia during sleep and reflects sleep need. We propose that endocytic trafficking through the BBB represents a function of sleep.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255390PMC
http://dx.doi.org/10.7554/eLife.43326DOI Listing

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