The study investigated the combination effects of the mixture of croscarmellose sodium and Pleurotus tuber-regium powder on the granules and tableting parameters of paracetamol tablets. Five batches (A-E) of paracetamol tablets were formulated using wet granulation method with various combination ratios of croscarmellose sodium and Pleurotus tuber-regium powder as disintegrant incorporated both intra- and extra granularly. Their granule properties such as bulk and tapped densities, angle of repose, Carr's index, Hausner's ratio and post compression parameters such as friability, hardness, disintegration time and drug release profiles were evaluated. The results showed a decrease in disintegration time with increasing concentration of Pleurotus tuber-regium powder with disintegration times < 3.58 min. There was an increase in hardness (values > 4.34 kp) and a decrease in friability (values < 0.6 %) of the tablets with increasing concentrations of Pleurotus tuber-regium. All the tablets exhibited comparable drug release profiles with over 80 % of their drugs released in 1 h. Harder and less friable fast disintegrating tablets of paracetamol can be obtained with Pleurotus tuber-regium powder in combination with croscarmellose sodium. The combination of croscarmellose sodium and Pleurotus tuber-regium possesses potentiative effect on their disintegrant activity.
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