AI Article Synopsis
- The review focuses on the development of LuxS enzyme inhibitors, specifically S-ribosylhomocysteine analogues, aimed at disrupting quorum sensing in bacteria.
- It summarizes various synthesized compounds that inhibit the LuxS enzyme, along with any available biological activity results.
- The authors conducted a comprehensive search of scientific databases and noted that there is still limited information in this research area, indicating a need for further studies.
Article Abstract
Design and synthesis of LuxS enzyme inhibitors otherwise known as S-ribosylhomocysteine analogues, to target quorum sensing in bacteria, has been considerably developed within the last decade. This review presents which molecules have been synthesized to target LuxS enzyme in other words inhibitors of S-ribosylhomocysteinase. It reports their tested biological activity as LuxS inhibitors when available. A systematic overview has been conducted by searching PubMed, Medline, and The Cochrane Library and data extraction of all synthesized S-ribosylhomocysteine analogues has been collected. This mini-review shows limited data to date on this area and should continue to be studied.
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| http://dx.doi.org/10.1016/j.bmc.2018.11.026 | DOI Listing |
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