Purpose: To compare the volumetric occlusion break surge responses of phacoemulsification units from 1 company over 3 generations under varying vacuum limits and target intraocular pressure (IOP) settings.
Setting: Alcon Research, Ltd., Lake Forest, California, USA.
Design: Experimental study.
Methods: Three generations of phacoemulsification units (Infiniti Vision System, Centurion Vision System, and Centurion Vision System with Active Sentry upgrades) were tested. Volumetric surge responses were measured after occlusion breaks at vacuum limits of 200 mm Hg, 300 mm Hg, 400 mm Hg, 500 mm Hg, and 600 mm Hg and target IOPs of 30 mm Hg, 55 mm Hg, and 80 mm Hg. An acrylic test chamber with a piston attached to 3 springs modeled the human eye in this study. The springs were calibrated to mimic volumetric changes in the eye over a wide range of IOPs.
Results: Occlusion break surge volumes varied from 17.4 μL to 153 μL, corresponding to 7% and 61%, respectively, of the aqueous volume in the average phakic eye and to 4% and 33% of the aqueous volume in the average aphakic eye.
Conclusion: Occlusion break surge volumes decreased with increasing target IOP, decreasing vacuum limit, and each generational increment in the phacoemulsification system.
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http://dx.doi.org/10.1016/j.jcrs.2018.01.032 | DOI Listing |
Clin Ophthalmol
January 2025
Department of Ophthalmology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan.
Purpose: The factors that contribute to the progression of macular involvement in RRD have not been extensively investigated. The purpose of this study is to evaluate the association between the preoperative characteristics and macular status of the eyes with rhegmatogenous retinal detachment (RRD).
Methods: This is a retrospective cohort study.
Cardiovasc Hematol Agents Med Chem
December 2024
Department of Pharmacology, Rungta College of Pharmaceutical Science and Research, Bhilai, Chhattisgarh, 490023, India.
Red blood cells with sickle cell anemia (SCA) have an irregular shape, and it is a genetic blood condition that can cause several problems and shorten life expectancy. Traditional treatments have focused on symptom management, but recent advancements in drug delivery systems offer promising pathways for targeted therapies. This abstract explores novel approaches to combat SCA through innovative drug delivery systems, gene therapy, and new pharmaceutical interventions.
View Article and Find Full Text PDFUpdates Surg
November 2024
Division of Hepatobiliary and General Surgery, Department of Surgery, IRCCS Humanitas Research Hospital, Via Manzoni 56, Rozzano, 20089, Milan, Italy.
We, herein, describe a case of complex parenchyma-sparing hepatectomy for multiple bilobar colorectal liver metastases (CRLMs). A 61-year-old woman, previously operated for an occlusive adenocarcinoma of the transverse colon and undergoing adjuvant chemotherapy, developed metachronous bilobar CRLMs. After administration of a II line chemotherapy with partial response, she was referred to our hospital.
View Article and Find Full Text PDFJ Clin Med
October 2024
Biomedical Physics Laboratory, National Cancer Institute, Santariskių Str. 1, LT 08660 Vilnius, Lithuania.
Meibomian gland dysfunction (MGD) and dry eye syndrome (DES) are common eye diseases characterized by altered tear film stability and inflammation of the ocular surface, causing significant discomfort and possible visual impairment. This study aimed to investigate the efficacy of curcumin-loaded liposomes (Lipo@Cur) compared to cyclosporine A-loaded liposomes (Lipo@CycA) in experimental rabbit models of MGD and DES, with a focus on their ability to improve tear film stability and reduce ocular surface inflammation. MGD and DES were induced using complete Freund's adjuvant (CFA) and treated to evaluate the effect of liposomal formulations on tear break-up time (TBUT), clinical signs of inflammation (telangiectasia, conjunctival hyperemia, meibomian foramen occlusion), and corneal as well as conjunctival histological cells.
View Article and Find Full Text PDFSci Rep
October 2024
Université Grenoble Alpes, CNRS, Laboratoire Interdisciplinaire de Physique, 38000, Grenoble, France.
The glycocalyx is a complex layer of carbohydrate and protein molecules that surrounds the cell membrane of many types of mammalian cells. It serves several important functions, including cell adhesion and communication, and maintain cell shape and stability, especially in the case of erythrocytes. Alteration of glycocalyx composition represents a cardiovascular health threatening.
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