AI Article Synopsis
- Acute ischemic stroke is a major cause of disability in the U.S., and treatments focus on reducing the impact of clots while minimizing the risk of lasting damage.
- Tenecteplase, a newer fibrinolytic treatment, shows promise as an alternative to the traditional tPA by having greater specificity for clot types and potentially lower bleeding risks.
- Current guidelines suggest tenecteplase can be used for mild acute ischemic stroke patients, but more research is needed to understand its role and weigh the risks versus benefits of this therapy.
Article Abstract
Introduction: Acute ischemic stroke is a leading cause of disability in the United States. Treatment is aimed at reducing impact of cerebral clot burden and life-long disability. Traditional fibrinolytic treatment with recombinant tissue plasminogen activator (tPA) has shown to be effective but at high risk of major bleeding. Multiple studies have evaluated tenecteplase as an alternative to tPA.
Objective: This review evaluates literature and utility of tenecteplase for treatment of acute ischemic stroke.
Discussion: Tenecteplase is modified, third generation fibrinolytic with greater specificity for fibrin bound clots. Current data in acute myocardial infarction suggest decreased bleeding events compared to alteplase. Multiple trials have investigated superiority of tenecteplase compared to tPA for treatment of acute ischemic stroke. Current guidelines designate tenecteplase as an alternative treatment for mild acute ischemic stroke patients based on recent literature.
Conclusion: Recent emerging literature and limited recommendation guidance from governing medical societies leave many emergency medicine providers to weigh benefit versus risk of fibrinolytic therapy and tenecteplase's place in therapy. This review evaluates the available literature regarding tenecteplase and its utility in the treatment of acute ischemic stroke patients.
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| http://dx.doi.org/10.1016/j.ajem.2018.11.018 | DOI Listing |
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