AI Article Synopsis
- Pancreas transplantation can effectively treat insulin-dependent diabetes, enhancing patient survival and quality of life, especially when done alongside kidney transplants.
- Success relies heavily on careful selection of both donors and recipients, with various technical methods available for implantation.
- Complications after surgery are mostly technical in the first year and immunological later, while islet cell transplantation yields poorer results compared to whole-organ pancreas transplantation.
Article Abstract
Pancreas transplantation treats insulin-dependent diabetes with or without concurrent end-stage renal disease. Pancreas transplantation increases survival versus no transplant, increases survival when performed as simultaneous pancreas-kidney versus deceased-donor kidney alone, and improves quality of life. Careful donor and recipient selection are paramount to good outcomes. Several technical variations exist for implantation: portal versus systemic vascular drainage and jejunal versus duodenal versus bladder exocrine drainage. Complications are most frequently technical in the first year and immunologic thereafter. Graft rejection is challenging to diagnose and is treated selectively. Islet cell transplantation currently has inferior outcomes to whole-organ pancreas transplantation.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.suc.2018.09.007 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!