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Gold-catalyzed post-MCR transformations towards complex (poly)heterocycles. | LitMetric

Gold-catalyzed post-MCR transformations towards complex (poly)heterocycles.

Drug Discov Today Technol

Laboratory for Organic & Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, University of Leuven (KU Leuven), Celestijnenlaan 200F, B-3001, Leuven, Belgium; Peoples Friendship University of Russia (RUDN University), Miklukho-Maklaya Street 6, 117198 Moscow, Russia. Electronic address:

Published: November 2018

AI Article Synopsis

Article Abstract

Post multicomponent reaction (MCR) transformations are one of the most successful methods leading to high structural diversity and molecular complexity. A well-known MCR, the Ugi reaction typically affords a linear peptide backbone, enabling post-Ugi transformations as an elegant solution to rigidify the Ugi adduct into more drug-like species. Not surprisingly, the development of such transformations leading to new structural frameworks has expanded rapidly over the last few years. These reactions have reached an impressive level of performance and versatility, particularly in amalgamation with gold catalysis. This review outlines the developments achieved in the past decade, highlighting the modifications that are performed in a sequential or domino fashion with emphasis on major concepts, synthetic applications of the derived products as well as mechanistic aspects.

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Source
http://dx.doi.org/10.1016/j.ddtec.2018.08.003DOI Listing

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Gold-catalyzed post-MCR transformations towards complex (poly)heterocycles.

Drug Discov Today Technol

November 2018

Laboratory for Organic & Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, University of Leuven (KU Leuven), Celestijnenlaan 200F, B-3001, Leuven, Belgium; Peoples Friendship University of Russia (RUDN University), Miklukho-Maklaya Street 6, 117198 Moscow, Russia. Electronic address:

Post multicomponent reaction (MCR) transformations are one of the most successful methods leading to high structural diversity and molecular complexity. A well-known MCR, the Ugi reaction typically affords a linear peptide backbone, enabling post-Ugi transformations as an elegant solution to rigidify the Ugi adduct into more drug-like species. Not surprisingly, the development of such transformations leading to new structural frameworks has expanded rapidly over the last few years.

View Article and Find Full Text PDF

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