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HIV-RNA decay in paired blood and semen samples of subjects receiving their first dolutegravir-based ART regimen. | LitMetric

AI Article Synopsis

  • Researchers aimed to examine how well a first-line DTG-based ART regimen lowers HIV-RNA levels in semen compared to blood plasma in HIV-infected men.
  • In a prospective study, ART-naïve participants starting treatment were monitored over 24 weeks, with blood and semen samples collected at various points to measure HIV-RNA levels.
  • Results showed that DTG effectively reduced HIV-RNA in both fluids, but discrepancies were noted, with some individuals having detectable levels in one fluid but not the other, demonstrating varying response rates to treatment.

Article Abstract

Background And Objectives: We aimed to investigate to what extent a first-line DTG-based ART regimen reduces HIV-RNA in semen compared to plasma.

Study Design: In this prospective, observational study, ART-naïve, HIV-infected males starting their first ART regimen with DTG plus TDF/FTC or ABC/3TC were enrolled. Paired blood (BP) and seminal plasma (SP) samples were collected at baseline (T0) and at week-2/4/12/24 after ART initiation. Sexually transmitted infections (STI) were ruled out before enrolment.

Results: Median baseline HIV-RNA levels were lower in SP compared to BP (657 versus 38.200 copies/ml, p < 0.001), three subjects had undetectable semen HIV-RNA. After 12 weeks of treatment, HIV-RNA was below the quantification limit in both BP and SP of 11 pts (61.1%). Discordant results were obtained in 6 subjects (33.3%), showing quantifiable HIV-RNA in blood only (2 cases) and in semen only (4 cases). Finally, one subject had a positive HIV-RNA in SP/BP. At W24, only in 2/16 subjects (12.5%) HIV-RNA was detectable in semen, while in the others it was negative on SP/BP. No concurrent STI was found in subjects with detectable VL in semen.

Conclusions: DTG demonstrated effectiveness in reducing VL with different kinetics in blood and semen, despite seminal viral suppression after 6 months of ART was not obtained in the totality of subjects.

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Source
http://dx.doi.org/10.1016/j.jcv.2018.11.002DOI Listing

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