The notion of tumor microenvironment (TME) has been brought to the forefront of recent scientific literature on cancer. However, there is no consensus on how to define and spatially delineate the TME. We propose that the time is ripe to go beyond an all-encompassing list of the components of the TME, and to construct a multilayered view of cancer. We distinguish six layers of environmental interactions with the tumor and show that they are associated with distinct mechanisms, and ultimately with distinct therapeutic approaches.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.trecan.2018.10.002 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Dissecting the cellular architecture and genetic circuitry of the soybean seed.
Proc Natl Acad Sci U S A
January 2025
Department of Plant Biology, College of Biological Sciences, University of California, Davis, CA 95616.
Seeds are complex structures composed of three regions, embryo, endosperm, and seed coat, with each further divided into subregions that consist of tissues, cell layers, and cell types. Although the seed is well characterized anatomically, much less is known about the genetic circuitry that dictates its spatial complexity. To address this issue, we profiled mRNAs from anatomically distinct seed subregions at several developmental stages.
View Article and Find Full Text PDFThe 1831 CE mystery eruption identified as Zavaritskii caldera, Simushir Island (Kurils).
Proc Natl Acad Sci U S A
January 2025
Archaeology & Palaeoecology, School of Natural and Built Environment, Queen's University, Belfast BT9 3AZ, United Kingdom.
Polar ice cores and historical records evidence a large-magnitude volcanic eruption in 1831 CE. This event was estimated to have injected ~13 Tg of sulfur (S) into the stratosphere which produced various atmospheric optical phenomena and led to Northern Hemisphere climate cooling of ~1 °C. The source of this volcanic event remains enigmatic, though one hypothesis has linked it to a modest phreatomagmatic eruption of Ferdinandea in the Strait of Sicily, which may have emitted additional S through magma-crust interactions with evaporite rocks.
View Article and Find Full Text PDFUltrasound pupillometry for the detection of a relative afferent pupillary defect (RAPD): Systematic evaluation in patients with optic neuritis and comparison with infrared video pupillometry.
PLoS One
January 2025
Department of Neurology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Purpose: A relative afferent pupillary defect (RAPD) is a characteristic clinical sign of optic neuritis (ON). Here, we systematically evaluated ultrasound pupillometry (UP) for the detection of an RAPD in patients with ON, including a comparison with infrared video pupillometry (IVP), the gold standard for objective pupillometry.
Materials And Methods: We enrolled 40 patients with acute (n = 9) or past (n = 31) ON (ON+), 31 patients with multiple sclerosis (MS) without prior ON, and 50 healthy controls (HC) in a cross-sectional observational study.
An Atomistic Analysis of the Carpet Growth of KCl Across Step Edges on the Ag(111) Surface.
J Phys Chem Lett
January 2025
Clausius Institut für Physikalische und Theoretische Chemie, Universität Bonn, Bonn 53115, Germany.
The carpet growth of alkali halide (AH) layers across step edges of substrates enables the growth of seamless and continuous large domains. Yet, information about how the AH layer adapts continuously to the height difference between the terraces on the two sides of a step is only described by continuum models, which do not give details of the ionic displacements. Here, we present a first study of thin epitaxial KCl(100) layers grown on the Ag(111) surface by scanning tunneling microscopy that provides atomistic details for the first time.
View Article and Find Full Text PDFMicrobial-induced Synthesis of nano NiFe LDH for High-efficiency Oxygen Evolution.
Chemistry
January 2025
Wuhan University of Technology - Mafangshan Campus: Wuhan University of Technology, School of Material Science and Engineeringl, CHINA.
NiFe layered double hydroxide (LDH) currently are the most efficient catalysts for the oxygen evolution reaction (OER) in alkaline environments. However, the development of high-performance low cost OER electrocatalysts using straightforward strategies remains a significant challenge. In this study, we describe an innovative microbial mineralization-based method for in situ-induced preparation of NiFe LDH nanosheets loaded on nickel foam and demonstrate that this material serves as an efficient oxygen evolution electrocatalyst.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!