AI Article Synopsis
- Mulberry root bark (MRB) was extracted with methanol, revealing the ethyl acetate fraction as the most effective at reducing inflammation.
- Compounds sanggenon B, albanol B, and sanggenon D displayed the ability to inhibit nitric oxide production in immune cells stimulated by a bacterial component.
- Albanol B, in particular, showed strong anti-inflammatory properties by lowering levels of pro-inflammatory cytokines and reducing the expression of iNOS and COX-2, suggesting its potential for new anti-inflammatory drug development.
Article Abstract
Mulberry ( L.) root bark (MRB) was extracted using methanol and the extracts were subjected to tests of anti-inflammatory effects. The ethyl acetate fraction demonstrated the best anti-inflammatory effects. Purified compounds, sanggenon B, albanol B and sanggenon D, showed inhibitory effects on NO production in LPS-stimulated RAW264.7 cells and albanol B demonstrated the best anti-inflammatory effects. Regarding the underlying molecular mechanisms, further investigations showed that treatments with Albanol B reduced production of pro-inflammatory cytokines and decreased expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). These results would contribute to development of novel anti-inflammatory drugs from MRB.
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| http://dx.doi.org/10.1080/14786419.2018.1527832 | DOI Listing |
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