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Molecular and Cellular Functions of the Warsaw Breakage Syndrome DNA Helicase DDX11. | LitMetric

Molecular and Cellular Functions of the Warsaw Breakage Syndrome DNA Helicase DDX11.

Genes (Basel)

Elettra⁻Sincrotrone Trieste S.C.p.A., AREA Science Park Basovizza, 34149 Trieste, Italy.

Published: November 2018

DDX11/ChlR1 (Chl1 in yeast) is a DNA helicase involved in sister chromatid cohesion and in DNA repair pathways. The protein belongs to the family of the iron⁻sulphur cluster containing DNA helicases, whose deficiencies have been linked to a number of diseases affecting genome stability. Mutations of human DDX11 are indeed associated with the rare genetic disorder named Warsaw breakage syndrome, showing both chromosomal breakages and chromatid cohesion defects. Moreover, growing evidence of a potential role in oncogenesis further emphasizes the clinical relevance of DDX11. Here, we illustrate the biochemical and structural features of DDX11 and how it cooperates with multiple protein partners in the cell, acting at the interface of DNA replication/repair/recombination and sister chromatid cohesion to preserve genome stability.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266566PMC
http://dx.doi.org/10.3390/genes9110564DOI Listing

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