AI Article Synopsis
- The study investigates the impact of 5,10-MTHFR gene polymorphisms on male infertility, focusing on the C665T and A1298C variants.
- It involved genotyping and statistical analysis of 232 infertile men and 114 controls, alongside a meta-analysis comparing 6180 patients and 5744 controls in Caucasian populations.
- The findings suggest the A1298C variant is more significantly associated with infertility, particularly in low-income groups, and improving dietary folate may help address this issue.
Article Abstract
Aim: 5,10-MTHFR-single nucleotide polymorphisms are important for normal functioning of the enzyme that plays a key role in DNA synthesis, folate metabolism and methylation reactions. Methodology & results: Male infertility association of C665T and A1298C polymorphisms was explored, this topic is still debatable. Infertile men (232) and controls (114) were genotyped and statistically analyzed. Comparison of patients (6180) and controls (5744) of Caucasian populations was performed by meta-analysis. Pooled results showed A1298C minor allele and homozygous genotype to be of a significantly higher frequency in the low-income group. Increase in per capita income has shown an increasing trend in the minor allele frequency in various world populations, potentially due to dietry-folate compensation.
Conclusion: A1298C seems more relevant marker than C665T for infertility association in Caucasian populations and may be addressed by improving dietary folate.
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| http://dx.doi.org/10.2217/pme-2018-0045 | DOI Listing |
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