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Human biomonitoring of essential and toxic trace elements (heavy metals and metalloids) in urine of children, teenagers, and young adults from a Central European Cohort in the Czech Republic.
J Expo Sci Environ Epidemiol
October 2024
RECETOX, Faculty of Science, Masaryk University, Kotlarska 2, Brno, Czech Republic.
Article Synopsis
- The study investigated urinary concentrations of 14 trace elements in 711 individuals from the Czech Republic to understand their exposure levels, including toxic metals and essential elements, and their health impacts.
- Young adults had higher levels of toxic elements, while children showed elevated levels of essential ones, with dietary factors like seafood and mushroom consumption influencing trace element concentrations.
- A significant percentage of participants exceeded the recommended health-based guidance values for arsenic and essential trace elements like zinc, indicating potential health risks associated with both deficiencies and excesses in trace element intake.*
A novel low shrinkage dimethacrylate monomer as an alternative to BisGMA for adhesive and resin-based composite applications.
Braz Oral Res
October 2024
Oregon Health & Science University, School of Dentistry, Department of Restorative Dentistry, Portland, OR, EUA.
The aim of this study was to develop a mixture of dimethacrylate isomers (PG6EMA) as a potential monomer for dental adhesives and composites. PG6EMA was synthesized de novo and characterized in the presence of ethanol (3%, 6% or 9%). BisGMA/TEGDMA (BTEG, 50/50 wt.
View Article and Find Full Text PDFEvaluation of Cytotoxic Effects of Purified Mercury in Human Gingival Fibroblasts- Study.
J Pharm Bioallied Sci
July 2024
Department of Pediatric and Preventive Dentistry, A J Institute of Dental Sciences, Kuntikana, Mangalore, Karnataka, India.
Article Synopsis
- Concerns about mercury toxicity from amalgam fillings have led to the exploration of ayurvedically purified mercury (AP-Hg) as a potentially safer alternative for dental treatment.
- Human gingival fibroblasts (HGF) were tested with commercially available mercury (CA-Hg) and AP-Hg at various concentrations, and cell viability was assessed after 24 and 48 hours.
- Results showed that AP-Hg led to higher cell viability and less cytotoxicity compared to CA-Hg, particularly significant at lower concentrations and over a longer period.
Background: In light of the Minamata Convention on Mercury and efforts to phase down dental amalgam use, tracking dental amalgam proportions across US Food and Drug Administration (FDA)-identified at-risk populations is of interest to optimize material selection aligned with patient needs.
Methods: A retrospective observational study of Epic's Cosmos electronic health records data set was conducted to calculate the rates of dental amalgam restorations from 2017 through 2023 and stratified using the social vulnerability index (quartile 4 indicates the highest social vulnerability and quartile 1 indicates the lowest) and payer type (Medicare, Medicaid, self-pay, miscellaneous or other). The authors included the following FDA-identified at-risk populations: pregnant people, children younger than 6 years, people with preexisting neurologic conditions, and people with impaired kidney function (n = 1,897,976).
pQEB1: a hospital outbreak plasmid lineage carrying .
Microb Genom
September 2024
Institute of Microbiology and Infection, School of Medical and Dental Sciences, The University of Birmingham, Edgbaston B15 2TT, UK.
While conducting genomic surveillance of carbapenemase-producing (CPE) from patient colonisation and clinical infections at Birmingham's Queen Elizabeth Hospital (QE), we identified an N-type plasmid lineage, pQEB1, carrying several antibiotic resistance genes, including the carbapenemase gene . The pQEB1 lineage is concerning due to its conferral of multidrug resistance, its host range and apparent transmissibility, and its potential for acquiring further resistance genes. Representatives of pQEB1 were found in three sequence types (STs) of , two STs of , and three species of .
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