AI Article Synopsis
- The research introduces a new method for directly modifying benzo[b]furans using common chemicals like disulfides and N-halosuccinimides without needing metals.
- This process generates various 3-halo-2-thiobenzo[b]furans, with yields ranging from moderate to excellent, showcasing its efficiency.
- Specifically, the presence of halogens (like bromo or iodo) on the benzo[b]furan makes it easier to create even more diverse compounds afterwards.
Article Abstract
The first example of the direct halosulfenylation of benzo[b]furans with commercially available disulfides and N-halosuccinimides has been achieved, providing an efficient metal-free synthetic pathway to access diverse 3-halo-2-thiobenzo[b]furans in moderate to excellent yields. In particular, a halogen (e.g., bromo or iodo) substituent on the benzo[b]furan ring is amenable for further synthetic elaborations thereby broadening the diversity of the products.
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| http://dx.doi.org/10.1039/c8ob02680g | DOI Listing |
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