AI Article Synopsis
- The study aimed to examine the link between the survivin c.-31G>C gene polymorphism and urinary system cancers through a meta-analysis.
- After analyzing various studies, results indicated that the c.-31G>C variation is significantly associated with increased risk of urinary tract cancers in different genetic models.
- The authors concluded that this genetic variation may be a risk factor for these cancers, but suggested that more diverse studies are needed for a clearer understanding.
Article Abstract
Aim: To investigate the possible association between survivin c.-31G>C (rs9904341) gene polymorphism and urinary system cancers by a meta-analysis approach.
Methods: Standard electronic literature databases were searched to find eligible studies. The odds ratios (ORs) with 95% CIs were estimated to find the associations possibility.
Results: Overall meta-analysis revealed significant associations between c.-31G>C transversion and risk of urinary tract cancers in dominant (OR: 1.34; 95% CI: 1.02-1.75; p = 0.035), recessive (OR: 1.52; 95% CI: 1.33-1.74; p < 0.001) and homozygote codominant (OR: 1.90; 95% Cl: 1.37-2.62; p < 0.001) genetic models.
Conclusion: The c.-31G>C transversion might be a risk factor for urinary system cancers. However, more articles with different ethnicities will help to obtain a more accurate conclusion.
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| http://dx.doi.org/10.2217/pme-2018-0053 | DOI Listing |
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