AI Article Synopsis
- A 69-year-old woman diagnosed with sarcoidosis experienced a significant decrease in angiotensin converting enzyme levels over four years, leading to the discovery of small cell lung cancer (SCLC).
- The SCLC was effectively treated with chemotherapy, specifically amrubicin, without worsening her existing sarcoidosis, despite amrubicin's known risks for lung complications.
- The case suggests a potential link between sarcoidosis and tumor immunity, with implications for understanding how immune responses may affect cancer development and treatment.
Article Abstract
A 69-year-old woman was diagnosed with sarcoidosis, which was not treated with corticosteroid therapy. Her levels of angiotensin converting enzyme decreased significantly over 4 years and a mass lesion was detected near the lower part of her left main bronchus, and diagnosed as small cell lung cancer (SCLC). Treatment of the SCLC with a series of chemotherapeutic agents produced excellent results. The pulmonary sarcoidosis did not show any deterioration despite the frequent use of amrubicin, which is known to be a cause of interstitial pneumonia. This is a case report of SCLC complicated with sarcoidosis in a stage of spontaneous remission, possibly suggesting an association between sarcoidosis and tumor immunity, since recent reports have suggested that immune checkpoint inhibitors might be involved in the development of sarcoidosis.
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| http://dx.doi.org/10.1272/jnms.JNMS.2018_85-47 | DOI Listing |
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