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Clinical use of molecular methods for infection in endemic and non-endemic countries: Benefits, limitations and challenges.
Front Parasitol
November 2023
Drugs for Neglected Diseases initiative, Latin America, Rio de Janeiro, Brazil.
infection is diagnosed by parasitological, molecular, and serological tests. Molecular methods based on DNA amplification provide a more sensitive alternative to classical parasitological techniques for detecting evidence of parasitemia, and are the preferred tests for congenital and oral transmission cases and parasite reactivation in chronically infected immunosuppressed individuals. In newborns at risk of vertical transmission, simplified diagnostic algorithms that provide timely results can reduce the high follow-up losses observed with current algorithms.
View Article and Find Full Text PDFThe Relationship Between Physical Activity Levels and Periodontal Health Status Among College Students: A Cross-Sectional Study.
Risk Manag Healthc Policy
January 2025
Shanghai Engineering Research Center of Tooth Restoration and Regeneration & Tongji Research Institute of Stomatology & Department of Implantology, Stomatological Hospital and Dental School, Tongji University, Shanghai, People's Republic of China.
Objective: This study aimed to investigate the relationship between physical activity levels and periodontal health status among college students in Shanghai, with the goal of informing oral health policy recommendations.
Methods: A cross-sectional study was conducted from March 2023 to March 2024 involving 120 university students aged 18-29. Data was collected using the World Health Organization (WHO) oral health survey methods.
A roadmap toward promoting and improving brain health in Europe and closing the awareness and funding gap.
Eur J Neurol
January 2025
Department of Neurology, Inselspital, University of Bern, Bern, Switzerland.
Background And Purpose: The global burden of neurological diseases exceeds 43.1%, imposing a significant burden on patients, caregivers and society. This paper presents a roadmap to reduce this burden and improve brain health (BH) in Europe.
View Article and Find Full Text PDFAssociation between combined healthy lifestyles and infertility: a cross-sectional study in US reproductive-aged women.
BMC Public Health
January 2025
Reproductive Medicine Centre, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, 518035, China.
Background: Infertility is a widespread problem for couples worldwide, and lifestyle factors are the cornerstone of infertility prevention. This research seeks to explore the association between combined healthy lifestyles and infertility risk among women of reproductive age.
Methods: This study analyzed data from the National Health and Nutrition Examination Survey (NHANES, 2013-2018), concentrating on 2,154 women aged 18 to 44.
Revealing excitation-inhibition imbalance in Alzheimer's disease using multiscale neural model inversion of resting-state functional MRI.
Commun Med (Lond)
January 2025
Department of Radiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Background: Alzheimer's disease (AD) is a serious neurodegenerative disorder without a clear understanding of pathophysiology. Recent experimental data have suggested neuronal excitation-inhibition (E-I) imbalance as an essential element of AD pathology, but E-I imbalance has not been systematically mapped out for either local or large-scale neuronal circuits in AD, precluding precise targeting of E-I imbalance in AD treatment.
Method: In this work, we apply a Multiscale Neural Model Inversion (MNMI) framework to the resting-state functional MRI data from the Alzheimer's Disease Neuroimaging Initiative (ADNI) to identify brain regions with disrupted E-I balance in a large network during AD progression.
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