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Bacteria associated with canine pyometra and concurrent bacteriuria: A prospective study.

Vet Microbiol

December 2024

Veterinary Teaching Hospital, Faculty of Veterinary Medicine, University of Helsinki, P.O. Box 57 (Viikintie 49), Helsinki FI-00014, Finland.

Canine pyometra is a common and potentially life-threatening reproductive disorder in intact female dogs. This prospective study aimed to (1) investigate the bacterial spectrum and antimicrobial susceptibilities of bacterial isolates from the uterus and urine of dogs with pyometra, (2) assess the clonal relatedness and virulence factors of Escherichia coli isolates from individual dogs, and (3) determine the occurrence of concurrent and persistent bacteriuria or clinical urinary tract infections. Bacterial isolates from 208 uterine and 203 urine specimens collected during pyometra surgery were analyzed.

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Urinary tract infections (UTIs) and asymptomatic bacteriurias (ABU) represent a large field of interest for antimicrobial stewardship programmes especially after 2020 EUCAST update in antimicrobial susceptibility testing interpretation and the possible related increase in carbapenems' prescription rate. The aim of this study was to evaluate the impact of the 2020 EUCAST update on antibiotic prescription in UTI due to organism and their characteristics. A retrospective observational study.

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Objectives: Urinary tract infections (UTIs) are an important cause of empiric antibiotic (over)treatment at the emergency department (ED). To enhance empiric antibiotic choices, mapping the national and local microbiology and antimicrobial resistance (AMR) patterns is crucial. This study aims to examine resistance patterns at a Brussels ED and to identify risk factors for AMR to evaluate current treatment guidelines and help combat AMR.

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Importance: Enterococcus faecalis urinary tract infection (UTI) is common in postmenopausal females and these bacteria create biofilms that may reduce treatment efficacy. The role of local vaginal estrogen therapy in susceptibility to E. faecalis infection is unclear.

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Article Synopsis
  • Asymptomatic bacteriuria (ASB) is the presence of bacteria in urine without urinary tract infection symptoms, and treating it is generally not helpful.
  • The study aimed to lower unnecessary antibiotic treatment for ASB in emergency departments (EDs) in the Netherlands using an educational and feedback-based strategy.
  • Results showed a decrease in urinalyses ordered and a reduction in treatment duration for ASB patients, but there was no significant drop in the inappropriate use of antibiotics.
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