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| http://dx.doi.org/10.18632/oncoscience.459 | DOI Listing |
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Design and early progress of the Comparison of Anticoagulation and anti-Platelet Therapies for Intracranial Vascular Atherostenosis (CAPTIVA) trial.
Int J Stroke
January 2025
Medical University of South Carolina, Charleston, SC, USA.
Background: The usual antithrombotic treatment for symptomatic intracranial atherosclerotic stenosis (ICAS) consists of dual treatment with clopidogrel and aspirin for 90 days followed by aspirin alone but the risk of recurrent stroke remains high up to 12 months. The Comparison of Anticoagulation and anti-Platelet Therapies for Intracranial Vascular Atherostenosis (CAPTIVA) trial was designed to determine whether other combinations of dual antithrombotic therapy are superior to clopidogrel and aspirin.
Methods: CAPTIVA is an ongoing, prospective, double-blinded, three-arm clinical trial at over 100 sites in the United States and Canada that will randomize 1683 high-risk subjects with a symptomatic infarct attributed to 70-99% stenosis of a major intracranial artery to 12 months of treatment with (1) ticagrelor (180 mg loading dose, then 90 mg twice daily), (2) low-dose rivaroxaban (2.
Relatedness of White-Tailed Deer from Culling Efforts Within Chronic Wasting Disease Management Zones in Minnesota.
Pathogens
January 2025
U.S. Geological Survey, Pennsylvania Cooperative Fish and Wildlife Research Unit, 403 Forest Resources Building, The Pennsylvania State University, University Park, PA 16802, USA.
In white-tailed deer (), closely related females form social groups, avoiding other social groups. Consequently, females infected with chronic wasting disease (CWD) are more likely to infect social group members. Culling has been used to reduce CWD transmission in high-risk areas; however, its effectiveness in removing related individuals has not been assessed.
View Article and Find Full Text PDFVentilator-Associated Pneumonia After Cardiac Arrest and Prevention Strategies: A Narrative Review.
Medicina (Kaunas)
January 2025
Division of Pulmonary and Critical Care Medicine Mayo Clinic, Rochester, MN 55905, USA.
: Ventilator-associated pneumonia (VAP) poses a significant threat to the clinical outcomes and hospital stays of mechanically ventilated patients, particularly those recovering from cardiac arrest. Given the already elevated mortality rates in cardiac arrest cases, the addition of VAP further diminishes the chances of survival. Consequently, a paramount focus on VAP prevention becomes imperative.
View Article and Find Full Text PDFLong-Term Outcome Following Concomitant Surgical Ablation for Atrial Fibrillation at University Hospital Basel: A Retrospective Study.
Medicina (Kaunas)
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Heart Center Hirslanden Zurich, 8008 Zurich, Switzerland.
: This study aims to examine the success of concomitant surgical ablation in patients with atrial fibrillation after one, three, and five years. Additionally, important predictors for rhythm outcome and rates of permanent pacemaker implantations were analyzed. : In this retrospective study, we included patients who were referred to the University Hospital of Basel, Switzerland, between 2011 and 2017.
View Article and Find Full Text PDFChild Maltreatment and Medical Traumatic Stress-A Double-Edged Sword.
Children (Basel)
December 2024
Department of Behavioral Sciences, Ariel University, Ariel 40700, Israel.
Background/objectives: Medical procedures can be a traumatic event for both children and their parents. Children who have experienced maltreatment or early traumatic experiences are at a higher risk for various emotional, behavioral, and health issues, including declining mental health. This may include experiencing heightened distress following medical procedures.
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