Stable tissue-simulating phantoms with various water and lipid contents for diffuse optical spectroscopy.

Biomed Opt Express

Central Research Laboratory, Hamamatsu Photonics K. K., 5000, Hirakuchi, Hamakita-ku, Hamamatsu City, Shizuoka Pref., 434-8601, Japan.

Published: November 2018

We introduced a method for producing solid phantoms with various water-to-lipid ratios that can simulate the absorption, and to some extent the scattering characteristics of human breast tissue. We also achieved phantom stability for a minimum of one month by solidifying the emulsion phantoms. The characteristics of the phantoms were evaluated using the six-wavelength time-domain diffuse optical spectroscopy (TD-DOS) system we developed to measure water and lipid contents and hemoglobin concentration. The TD-DOS measurements were validated with a magnetic resonance imaging system.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238899PMC
http://dx.doi.org/10.1364/BOE.9.005792DOI Listing

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