AI Article Synopsis
- CTTN, a protein linked to cancer invasiveness, is found on chromosome 11 and may indicate prognosis for oral squamous cell carcinoma (OSCC) regarding recurrence and survival.
- Knockdown experiments showed that reduced CTTN levels in head and neck squamous cell carcinoma (HNSCC) led to decreased cell invasion, while gene expression profiling revealed deregulated genes tied to cancer progression.
- The study suggests that CTTN could aid in managing OSCC treatments and highlights potential new targets for personalized therapies based on CTTN signaling.
Article Abstract
Background: Cortactin (CTTN) is located on chromosome 11q13 and is associated with invasiveness in various cancer entities. CTTN protein expression could be a prognosticator of oral squamous cell carcinoma (OSCC) in terms of recurrence and survival.
Methods: CTTN-dependent invasion was performed using migration assay in human papillomavirus-negative head and neck squamous cell carcinoma (HNSCC) cells. Cortactin protein analysis in tissue microarrays was used for correlation with clinical parameters, as well as for survival analysis. Gene expression profiling in HNSCC cells was performed to unreveal CTTN signaling.
Results: Knockdown of CTTN in HNSCC cells showed less invasion in vitro. Gene expression profiling showed various deregulated genes known to be involved in progression. We confirmed the link between CTTN overexpression and progression in a large clinical cohort. High expression was associated with worse overall and progression-free survival.
Conclusions: We propose CTTN for managing OSCC in terms of adjuvant therapy and aftercare. Furthermore, our study reveals new potential targets in CTTN signaling for individualized OSCC therapy.
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| http://dx.doi.org/10.1002/hed.25515 | DOI Listing |
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