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http://dx.doi.org/10.1007/s13300-018-0538-6 | DOI Listing |
J Pharm Sci
December 2024
SSPC Centre for Pharmaceutical Research, School of Pharmacy, University College Cork, Cork, T12 YT20, Ireland. Electronic address:
With the increasing development of oral peptide dosage forms, a comprehensive understanding of factors affecting peptide drug stability in the solid-state is critical. This study used human insulin, as a model peptide, to examine the individual and interactive effects of temperature and humidity on its solid-state stability. Insulin was stored at temperature (25°C, 40°C, and 6 °C) and humidity (1%, 33% and 75%) over 6 months.
View Article and Find Full Text PDFFront Endocrinol (Lausanne)
December 2024
Department of Radiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
[This corrects the article DOI: 10.3389/fendo.2024.
View Article and Find Full Text PDFJ Anim Sci
December 2024
Centre for Animal Nutrition and Welfare, University of Veterinary Medicine Vienna, Veterinaerplatz 1, 1210 Vienna, Austria.
We recently reported factors leading to different severity of ruminal pH drop in primiparous cows fed the same diet during transition and early lactation. The present study evaluates the effects of those severities on performance and several blood and balance parameters in the same 24 primiparous cows from 3 wk before calving until wk 10 in lactation. Dietary concentrate was increased for all cows from 32 before calving to 60% (DM basis) over the first wk in lactation, resulting in a diet with 40% non-fiber carbohydrates (NFC), and 14.
View Article and Find Full Text PDFAmino Acids
December 2024
Department of Gastroenterology and Hepatology, Kohnodai Hospital, National Center for Global Health and Medicine, 1-7-1 Kohnodai, Ichikawa, Chiba, 272-8516, Japan.
Little is known about how blood free amino acids (FAAs) change in metabolic dysfunction-associated steatotic liver disease (MASLD). This study aims to identify the imbalance of FAAs in MASLD and explore its correction as a potential therapeutic target. We analyzed plasma FAAs data from 23,036 individuals with steatosis information from a biobank in Japan, and 310 patients with MASLD were enrolled.
View Article and Find Full Text PDFOphthalmol Sci
October 2024
Medical Information Center, Kyushu University Hospital, Fukuoka, Japan.
Purpose: Neurotrophic keratopathy is part of the leprosy sequelae and causes progressive deterioration of visual acuity. Although leprosy is bacteriologically curable, there is currently no efficient treatment. Eye drops containing tetrapeptides, phenylalanine-glycine-leucine-methionine-amide (FGLM-NH) and serine-serine-serine-arginine (SSSR), derived from substance P and insulin-like growth factor 1, are clinically efficacious in the treatment of corneal epithelial disorders caused by neurotrophic keratopathy.
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