We reported first data on the densities and chemical composition of fishing lines and fish hooks deposited on a Mediterranean beach. On a sampling area of 1.5 ha, we removed a total of 185,028 cm of fishing lines (density 12.34 cm/m) and 33 hooks (density 22 units/ha). Totally, 637.62 g (42.5 mg/m) of fishing lines were collected. We sampled 120 items entangled belongings to 7 animal taxa (density 6.49 items/100 m of fishing lines). We also observed a not quantifiable number of egagropiles (Posidonia oceanica spheroids), Rhodophyceae (Halymenia sp.) and segments of reeds of Phragmites communis, trapped in the fishing lines. Fourier transform infrared (FTIR) spectroscopy was used in order to identify the chemical composition of the fishing lines: 92% was made of nylon while 8.0% was determined as fluorocarbon based polymers (polyvinylidene fluoride). Because of their subtlety and reduced size, sandy beach cleaning operations should include at least two consecutive removal samplings: indeed, a part of this litter (12.14%) is not removed in the first sampling. The unexpected high density of fishing lines suggests specific management actions aimed to periodically remove this neglected anthropogenic litter.
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http://dx.doi.org/10.1007/s11356-018-3753-9 | DOI Listing |
Cell Biol Toxicol
January 2025
Department of Environmental Toxicology, Swiss Federal Institute of Aquatic Science and Technology, Eawag, 8600, Dübendorf, Switzerland.
Advancing in vitro systems to address the effects of chemical pollution requires a thorough characterization of their functionalities, such as their repertoire of biotransformation enzymes. Currently, knowledge regarding the presence, activity magnitudes, and inducibility of different biotransformation pathways in vitro is scarce, particularly across organs. We report organ-specific kinetics for phase I and II biotransformation enzymes, under basal and induced conditions, in two in vitro systems using salmonid fish: S9 sub-cellular fractions from brown trout (Salmo trutta) and rainbow trout (Oncorhynchus mykiss) were compared with rainbow trout cell lines.
View Article and Find Full Text PDFACS Appl Bio Mater
January 2025
Department of Applied Chemistry, Rajiv Gandhi Technological University, Bhopal 462033, Madhya Pradesh, India.
Deciphering the most promising strategy for the evolution of cancer patient management remains a multifaceted, challenging affair to date. Additionally, such approaches often lead to microbial infections as side effects, probably due to the compromised immunity of the patients undergoing such treatment. Distinctly, this work delineates a rational combinatorial strategy harnessing stereogenic harmony in the diphenylalanine fragment, tethering it to an amphiphile 12-hydroxy-lauric acid at the N-terminus (compounds -) such that a potential therapeutic could be extracted out from the series.
View Article and Find Full Text PDFJ Transl Med
January 2025
Fujian-Macao Science and Technology Cooperation Base of Traditional Chinese Medicine-Oriented Chronic Disease Prevention and Treatment, Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, 350001, China.
Background: Death-Associated Protein Kinase 1 (DAPK1) family members are calcium/calmodulin-regulated serine/threonine kinases implicated in cell death, normal development, and human diseases. However, the regulation of DAPK1 expression in cancer remains unclear.
Methods: We examined the expression and functional impact of a DAPK1 splice variant, DAPK1-215, in multiple cancer cell lines.
Front Pharmacol
January 2025
Department of Surgical Sciences, Functional Pharmacology and Neuroscience, Uppsala University, Uppsala, Sweden.
Background: Xanthones are dubbed as putative lead-like molecules for cancer drug design and discovery. This study was aimed at the synthesis, characterization, and target fishing of novel xanthone derivatives.
Methods: The products of reactions of xanthydrol with urea, thiourea, and thiosemicarbazide reacted with α-haloketones to prepare the thiazolone compounds.
Sci Total Environ
February 2025
Institute of Environmental Assessment and Water Research, CSIC, 08034 Barcelona, Spain. Electronic address:
Airborne quasi-ultrafine particle samples were collected from different outdoor sites in Barcelona (NE Spain, 35 samples) and the Valencia subway (about 400 km south of Barcelona, 3 samples). Locations and schedules were designed to cover cold and warm seasons and to represent the impact of different types of transport (cars, trains, ships, and planes). Extracts from PTFE filters (methanol:dichloromethane 1:2) were used to test toxic effects in human cell lines (Induction of reactive oxygen species, inflammatory response) and in zebrafish embryos (expression of xenobiotic response-related genes, cyp1a1, gsa1 and hao1).
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