•Primary mediastinal choriocarcinoma is rare, especially in female patients.•Genomic losses predominated our case, which has not been previously reported.•This tumor lacked human chorionic gonadotropin and required histologic diagnosis.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232631 | PMC |
| http://dx.doi.org/10.1016/j.gore.2018.10.013 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Primary mediastinal choriocarcinoma in a woman treated with VIP therapy instead of BEP therapy for the prevention of postoperative acute respiratory distress syndrome.
Int Cancer Conf J
October 2024
Department of Respiratory Medicine, University of Tsukuba Hospital, Tennodai 1-1-1, Tsukuba, Ibaraki 305-8575 Japan.
Article Synopsis
- Primary mediastinal germ cell tumor (PMGCT), particularly choriocarcinoma, has a poor prognosis and is treated with BEP therapy, which can lead to complications like acute respiratory distress syndrome (ARDS).
- A 38-year-old woman diagnosed with advanced primary mediastinal choriocarcinoma underwent BEP therapy, resulting in a significant reduction of hCG levels.
- To minimize the risk of ARDS, she switched to VIP therapy and successfully underwent surgical resection, remaining disease-free for 16 months post-surgery.
Tislelizumab for treatment of a pediatric patient with primary mediastinal choriocarcinoma: a case report.
Transl Pediatr
August 2024
Department of Oncology, Children's Hospital of Nanjing Medical University, Nanjing, China.
Article Synopsis
- Primary mediastinal choriocarcinoma (PCC) is a rare and aggressive tumor usually found in midline areas like the mediastinum, with no established treatment guidelines currently in place.
- A case involving a 15-year-old boy with severe symptoms and a large mediastinal mass revealed elevated tumor marker levels, indicating a germ cell tumor with lung metastasis.
- Treatment included chemotherapy and tislelizumab, resulting in significant improvement in symptoms and a decrease in beta-HCG levels, with the patient still alive as of March 2024.
Maediastinal germ cell tumors: analysis using hospital-based cancer registry data in Japan.
Int J Clin Oncol
November 2024
Department of Urology, Faculty of Medicine, University of Tsukuba, 1-1-1, Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.
Objectives: Mediastinal germ cell tumors are rare and few large-scale studies on mediastinal germ cell tumors are reported. We aimed to investigate the clinical characteristics and survival outcomes of patients with mediastinum germ cell tumors in Japan.
Methods: A hospital-based cancer registry data in Japan was used to identify and enroll patients diagnosed with mediastinal germ cell tumors in 2012-2013.
Pediatric primary extragonadal choriocarcinoma - A study on male patients at a single tertiary medical institution.
Pediatr Neonatol
June 2024
Department of Pediatrics, Taichung Veterans General Hospital, Taichung, Taiwan; Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taiwan; Hung Kuang University, Taichung, Taiwan; Institute of Biomedical Sciences, MacKay Medical College, New Taipei City, Taiwan. Electronic address:
Background: Primary extragonadal choriocarcinoma (PEGCC) in male is rare. It is highly malignant, typically presents with distant metastasis at the time of diagnosis, and responds poorly to treatment. Because of its associated high levels of PD-L1, the PD-1/PD-L1 pathway is a likely therapeutic target.
View Article and Find Full Text PDFPathogenesis and pathobiology of testicular germ cell tumours: a view from a developmental biological perspective with guidelines for pathological diagnostics.
Histopathology
November 2024
Institute of Pathology, University Medical Center, Göttingen, Germany.
Article Synopsis
- Testicular germ cell tumors (GCT) are split into three types based on how they develop and their characteristics: Type I (prepubertal), Type II, and Type III.
- Type I usually happens in kids and teens, while Type II comes from non-invasive germ cells and has a specific change on chromosome 12, and Type III happens in older men with changes on chromosome 9.
- Each type has different types of tumors and requires different treatments, with Type II being more complicated and worse to treat compared to the others.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!