This text presents complementary data corresponding to schistosomiasis mansoni׳s vector control and toxicity on cercariae using potassium usnate. This information support our research article "Potassium Usnate Toxicity Against Embryonic Stages of the Snail and Cercariae" [1], and focuses on the analysis of the detailed data regarding the different concentrations of potassium usnate and their efficiency to mortality and non-viability and cercariae mortality etiologic agent of the disease.
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http://dx.doi.org/10.1016/j.dib.2018.10.119 | DOI Listing |
Molecules
October 2021
Laboratório de Imunopatologia Keizo Asami (LIKA), Universidade Federal de Pernambuco, Avenida Prof. Moraes Rego, 1235 Cidade Universitária, Recife 50670-501, PE, Brazil.
Usnic acid is the best-studied lichen metabolite, presenting several biological activities, such as antibacterial, immunostimulating, antiviral, antifungal, anti-inflammatory, and antiparasitic agents; despite these relevant properties, it is a hydrophobic and toxic molecule. In this context, scientific research has driven the development of innovative alternatives, considering usnic acid as a source of raw material in obtaining new molecules, allowing structural modifications (syntheses) from it. The purpose is to optimize biological activities and toxicity, with less concentration and/or response time.
View Article and Find Full Text PDFPhytomedicine
October 2021
Division of Hemato-Oncology, Department of Internal Medicine, Chonnam National University Medical School and Hwasun Hospital, Hwasun, Republic of Korea; Combinatorial Tumor Immunotherapy MRC Center, Chonnam National University Medical School, Hwasun, Republic of Korea. Electronic address:
Background: Potassium usnate (KU), a water-soluble form of usnic acid, shows anticancer activity. However, the underlying mechanisms have not been fully elucidated.
Purpose: We aimed to identify the pathways involved in anticancer effects of KU in human gastric cancer (GC) and colorectal cancer (CRC) cells using RNA-sequencing (RNA-seq) based transcriptome analysis.
Acta Trop
October 2021
Departamento de Bioquímica, Centro de Biociências - CB, Universidade Federal de Pernambuco, Avenida Prof. Moraes Rego, 1235, Cidade Universitária, 50670-420, Recife-PE, Brazil. Electronic address:
Schistosomiasis is a public health problem in many developing countries. The mollusc Biomphalaria glabrata is the most important vector of Schistosoma mansoni in South America. The population control of this vector to prevent the spread of schistosomiasis is currently done with the application of highly toxic molluscicide to the environment.
View Article and Find Full Text PDFExp Parasitol
January 2020
Centro de Biociência, Departamento de Bioquímica, Universidade Federal de Pernambuco. Avenida Prof. Moraes Rego, 1235, Cidade Universitária, 50670-901, Recife, PE, Brazil. Electronic address:
Here, we report enhanced the in vitro effect of potassium usnate on coupled adult Schistosoma mansoni worms at different time intervals and concentrations. The evaluated schistosomicidal parameters were the following: motility, mortality, fecundity and integumentary changes, as viewed in photomicrographs. Potassium usnate was able to cause 100 and 50% mortality at 100 and 50 μM concentrations, respectively, after 24 h of exposure, while 25 and 12.
View Article and Find Full Text PDFData Brief
December 2018
Departamento de Bioquímica, Centro de Biociências, Universidade Federal de Pernambuco, Avenida Prof. Moraes Rego, 1235 Cidade Universitária, CEP 50670-901 Recife, PE, Brazil.
This text presents complementary data corresponding to schistosomiasis mansoni׳s vector control and toxicity on cercariae using potassium usnate. This information support our research article "Potassium Usnate Toxicity Against Embryonic Stages of the Snail and Cercariae" [1], and focuses on the analysis of the detailed data regarding the different concentrations of potassium usnate and their efficiency to mortality and non-viability and cercariae mortality etiologic agent of the disease.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!