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Sociodemographic Factors Associated with Improved Metabolic Syndrome in Slum Dwelling Adults in Kenya: A Randomized Controlled Trial.
SAGE Open Nurs
December 2024
School of Nursing Sciences, University of Nairobi, Nairobi, Kenya.
Background: Sociodemographic factors have been implicated in cardiovascular health with differential morbidity and mortality. It is essential to comprehend how sociodemographic factors contribute to the improvement of Metabolic Syndrome (MetS), the primary cardiovascular diseases indicator.
Objective: Determine the role of sociodemographic factors in improving MetS among adults residing in the Slums of Nairobi, Kenya.
Prevalence and Patterns of Polysubstance Use (Tobacco and Other Substances) and Associated Factors: A Cross-Sectional Analysis in a High-Risk Cohort for Oral Cancer in Varanasi, India, with a Special Focus on Young Emerging Adults.
Nicotine Tob Res
December 2024
Professor, Dept of Surgical Oncology, Tata Memorial Hospital, Homi Bhabha National Institute, Training School Complex, Anushakti Nagar, Mumbai, India.
Introduction: The dearth of population-based data on polysubstance use, especially in young emerging adults, presents a critical gap in understanding public health challenges, particularly in rural India, where tobacco and oral cancer are prevalent. This study addresses this gap by investigating the prevalence and patterns of substance use, with a focus on young emerging adults (18-29 years) within a high-risk cohort for oral cancer in Varanasi, India.
Methods: The study involved a cross-sectional analysis of baseline data from 10,101 participants within a high-risk cohort in rural settings of the Varanasi district between December 2020-June 2023.
Guselkumab in patients with moderately to severely active ulcerative colitis (QUASAR): phase 3 double-blind, randomised, placebo-controlled induction and maintenance studies.
Lancet
December 2024
Department of Medicine I, Agaplesion Markus Hospital, Goethe University, Frankfurt, Germany.
Background: Interleukin-23 inhibition is effective in treating ulcerative colitis. Guselkumab is a dual-acting, human IgG1, interleukin-23p19 subunit inhibitor that potently neutralises interleukin-23 and can bind to CD64. We aimed to evaluate the efficacy and safety of guselkumab as induction and maintenance therapy in patients with ulcerative colitis.
View Article and Find Full Text PDFThe Winner and still champion: Nodule volume doubling times.
Eur J Cancer
December 2024
Department of Diagnostic, Molecular, and Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address:
There have been enormous advances in the approach to assessing malignancy status of indeterminate pulmonary nodules including risk models, image based biomarkers and numerous types of biologic and molecular markers. All of these have the advantage of guiding further workup once the nodule is identified. The traditional method, especially for smaller nodules relies primarily on assessing whether a nodule changes in size over time and is a feature in virtually every management protocol for both screen detected as well as incidentally detected nodules.
View Article and Find Full Text PDF[Environmental exposures and epigenome changes within the first 1000 days of life].
Med Sci (Paris)
December 2024
Université Grenoble Alpes, Inserm, CNRS, Team of environmental epidemiology applied to development and respiratory health, IAB, Grenoble, France.
Article Synopsis
- Early environmental factors can impact a child's development and health in lasting ways.
- Epigenetic changes may help explain these long-term effects, highlighting the importance of studying them.
- The review focuses on recent research about common environmental exposures during the first 1000 days of life, such as tobacco, chemicals, air pollution, and temperature.
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