Seven studies evaluated pharmacological treatments and 12 studies evaluated non-pharmacological interventions including Cognitive Behavioural Therapy (CBT), minimal interventions toward patients, pharmacists or physicians, or dedicated visits, in order to discontinue benzodiazepines treatments. Among pharmacological treatments, only melatonin was significantly efficacious in patients suffering from insomnia alone. BCT showed efficacy in increasing self-efficacy feeling toward BZD cessation and in patients with sleep disorders. Minimal interventions and dedicated visits were significantly efficacious with favourable cost-effectiveness ratio. No study investigated patients with high-doses of benzodiazepine, or with addiction, somatic or psychiatric disorders.
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| http://dx.doi.org/10.1016/j.lpm.2018.10.007 | DOI Listing |
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