AI Article Synopsis
- The study investigates the long-term neurologic risks for children born via in vitro fertilization (IVF) or ovulation induction (OI) compared to those conceived naturally.
- Data from singleton births at Soroka University Medical Center from 1991 to 2014 was analyzed, linking perinatal outcomes with pediatric hospitalization records.
- Findings indicate that children from IVF (3.7%) and OI (4.1%) pregnancies experienced more neurologic issues, particularly attention deficit disorders and sleep disorders, with IVF identified as a significant risk factor for these problems.*
Article Abstract
Objective: To determine the risk of long-term neurologic morbidity among children (up to 18 years) born following in vitro fertilization (IVF) or ovulation induction (OI) treatments as compared with spontaneously conceived.
Study Design: A population-based cohort analysis was performed, including data from the perinatal computerized database on all singleton infants born at the Soroka University Medical Center (SUMC) between the years 1991 and 2014. This perinatal database was linked and cross-matched with the SUMC computerized dataset of all pediatric hospitalizations.
Results: Neurologic morbidity was significantly more common in IVF (3.7%) and OI (4.1%) offspring as compared with those following spontaneous pregnancies (3.1%; = 0.017). In particular, attention deficit/hyperactivity disorders and headaches were more common in the OI group and sleep disorders in the IVF group, whereas autism and cerebral palsy were comparable between the groups. In the Weibull multivariable analysis, while controlling for maternal age, preterm delivery, birthweight centile, maternal diabetes, and hypertensive disorders, IVF (adjusted hazard ratio [HR]: 1.40; 95% confidence interval [CI]: 1.14-1.71; = 0.001), but not OI (adjusted HR: 1.17' 95% CI: 0.92-1.48; = 0.196), was noted as an independent risk factor for long-term pediatric neurologic morbidity.
Conclusion: IVF offspring appear to be at an increased risk of long-term neurologic morbidity up to 18 years of age.
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| http://dx.doi.org/10.1055/s-0038-1675159 | DOI Listing |
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