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Dogs with diet-associated dilated cardiomyopathy have higher urine di-docosahexaenoyl (22:6)-bis(monoacylglycerol)phosphate, a biomarker of phospholipidosis.
Am J Vet Res
January 2025
Department of Comparative Pathobiology, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA.
Objective: In dogs with diet-associated dilated cardiomyopathy (DCM), we have identified electron microscopic changes suggestive of abnormal lysosomal accumulation of phospholipids and consistent with the appearance of drug-induced phospholipidosis in people and other animals. The objective of this study was to compare concentrations of urine di-docosahexaenoyl (22:6)-bis(monoacylglycerol)phosphate (BMP), a biomarker of drug-induced phospholipidosis, in dogs with DCM eating high-pulse (HP) diets, dogs with DCM eating low-pulse (LP) diets, and healthy controls (control-HP and control-LP).
Methods: In this cross-sectional study, voided urine was collected from client-owned dogs with DCM from September 2018 through March 2020.
Diet-associated Dilated Cardiomyopathy-The Issue Remains Unresolved.
J Nutr
November 2023
From the Veterinary Information Network, Davis, CA, United States.
Comparison of echocardiography, biomarkers and taurine concentrations in cats eating high- or low-pulse diets.
J Feline Med Surg
February 2023
Department of Biostatistics, Boston University, Boston, MA, USA.
Objectives: There are ongoing investigations into diet-associated dilated cardiomyopathy in dogs, but there has been minimal investigation into possible diet-associated dilated cardiomyopathy in cats. The objective of this study was to compare cardiac size and function, cardiac biomarkers and taurine concentrations in healthy cats eating high- vs low-pulse diets. We hypothesized that cats eating high-pulse diets would have larger hearts, lower systolic function and higher biomarker concentrations than cats eating low-pulse diets and that there would be no difference in taurine concentrations between the diet groups.
View Article and Find Full Text PDFMetabolomic profiling in dogs with dilated cardiomyopathy eating non-traditional or traditional diets and in healthy controls.
Sci Rep
December 2022
Department of Clinical Sciences, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA, USA.
Dilated cardiomyopathy (DCM), caused by genetic and environmental factors, usually progresses to heart failure, a major cause of death in elderly people. A diet-associated form of DCM was recently identified in pet dogs eating non-traditional (NT) diets. To identify potential dietary causes, we analyzed metabolomic signatures and gene set/pathway enrichment in (1) all dogs based on disease, diet, and their interactions and (2) dogs with DCM based on diet.
View Article and Find Full Text PDFComparison of echocardiographic measurements and cardiac biomarkers in healthy dogs eating nontraditional or traditional diets.
J Vet Intern Med
January 2023
Carlson College of Veterinary Medicine, Oregon State University, 700 SW 30th Street, Corvallis, Oregon, USA.
Background: There has been a recent association between nontraditional diets and development of diet-associated dilated cardiomyopathy (DCM) in dogs.
Hypothesis/objectives: To compare echocardiographic measurements and cardiac biomarkers between healthy dogs eating nontraditional vs traditional diets. We hypothesized that dogs eating nontraditional diets would have lower measures of systolic myocardial performance compared to dogs eating traditional diets.
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