Semiconducting polymer-based nanoparticles for photothermal therapy at the second near-infrared window.

Chem Commun (Camb)

The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou 350025, P. R. China and Mengchao Med-X Center, Fuzhou University, Fuzhou 350116, P. R. China and The Liver Center of Fujian Province, Fujian Medical University, Fuzhou 350025, P. R. China and Liver Disease Center, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, P. R. China and Department of Translational Medicine, Xiamen Institute of Rare Earth Materials, Chinese Academy of Sciences, Xiamen 361024, P. R. China.

Published: December 2018

We designed novel diketopyrrolopyrrole polymer based nanoparticles (DPP-IID-FA), which exhibited strong light absorption and excellent photothermal conversion in the NIR optical window, and displayed high biocompatibility and photostability. Furthermore, our nanoparticles could be efficiently uptaken by cancer cells and exhibited outstanding anticancer ability both in vitro and in vivo under NIR-II laser irradiation.

Download full-text PDF

Source
http://dx.doi.org/10.1039/c8cc07583bDOI Listing

Publication Analysis

Top Keywords

semiconducting polymer-based
4
polymer-based nanoparticles
4
nanoparticles photothermal
4
photothermal therapy
4
therapy second
4
second near-infrared
4
near-infrared window
4
window designed
4
designed novel
4
novel diketopyrrolopyrrole
4

Similar Publications

Hypoxia-tolerant polymeric photosensitizer prodrug for cancer photo-immunotherapy.

Nat Commun

January 2025

National Engineering Research Centre for Nanomedicine, College of Life Science and Technology, Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medical, Huazhong University of Science and Technology, Wuhan, PR China.

Although photodynamic immunotherapy represents a promising therapeutic approach against malignant tumors, its efficacy is often hampered by the hypoxia and immunosuppressive conditions within the tumor microenvironment (TME) following photodynamic therapy (PDT). In this study, we report the design guidelines towards efficient Type-I semiconducting polymer photosensitizer and modify the best-performing polymer into a hypoxia-tolerant polymeric photosensitizer prodrug (HTPS) for cancer photo-immunotherapy. HTPS not only performs Type-I PDT process to partially overcome the limitation of hypoxic tumors in PDT by recycling oxygen but also specifically releases a Signal Transducer and Activator of Transcription-3 (STAT3) inhibitor (Niclosamide) in response to a cancer biomarker in the TME.

View Article and Find Full Text PDF
Article Synopsis
  • - The text discusses new aerogels with low thermal conductivity that are integrated with spC-conjugated porous polymers (spC-CPPs), which serve as effective photosensitizers for applications like seawater desalination and uranium extraction.
  • - These spC-CPP aerogels are made using a method called surface-initiated aldol polycondensation (SI-AP), which allows for robust aerogels with excellent properties for energy conversion and uranium adsorption.
  • - Notably, the DHA-TMT aerogel shows exceptional performance in evaporation (1.55 kg/m²/h) and uranium extraction (up to 1200 mg/m²), while maintaining stability in harsh environments, highlighting a promising strategy for
View Article and Find Full Text PDF

Confined semiconducting polymers with boosted NIR light-triggered HO production for hypoxia-tolerant persistent photodynamic therapy.

Chem Sci

July 2024

State Key Laboratory of Organic Electronics and Information Displays, Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM), Nanjing University of Posts & Telecommunications Nanjing 210023 China

Article Synopsis
  • Hypoxia and the short lifespan of reactive oxygen species (ROS) limit the effectiveness of photodynamic therapy (PDT) in treating tumors, prompting the need for improved therapies.
  • Researchers developed a semiconducting polymer-based photosensitizer, PCPDTBT, which significantly enhances ROS generation when encapsulated in a mesoporous silica matrix, resulting in better PDT performance.
  • The addition of Fe ions increases drug loading capacity and enables continuous ROS production through a Fenton reaction after laser treatment, allowing for improved treatments in hypoxic tumor environments.
View Article and Find Full Text PDF

High-Precision Tailored Polymer Molecular Weights for Specific Photovoltaic Applications through Ultrasound-Induced Simultaneous Physical and Chemical Events.

Angew Chem Int Ed Engl

April 2024

School of Energy and Chemical Engineering, Perovtronics Research Center, Low Dimensional Carbon Materials Center, Ulsan National Institute of Science and Technology (UNIST), 50 UNIST-gil, Ulju-gun, Ulsan, 44919, South Korea.

It is highly challenging to reproducibly prepare semiconducting polymers with targeted molecular weight tailored for next-generation photovoltaic applications. Once such an easily accessible methodology is established, which can not only contribute to overcome the current limitation of the statistically determined nature of semiconducting polymers, but also facilitate rapid incorporation into the broad synthetic chemists' toolbox. Here, we describe a simple yet robust ultrasonication-assisted Stille polymerization for accessing semiconducting polymers with high-precision tailored molecular weights (from low to ultrahigh molecular weight ranges) while mitigating their interbatch variations.

View Article and Find Full Text PDF

This paper reports a new mechanism for particulate matter detection and identification. Three types of carbon particles are synthesized with different functional groups to mimic the real particulates in atmospheric aerosol. After exposing polymer-based organic devices in organic field effect transistor (OFET) architectures to the particle mist, the sensitivity and selectivity of the detection of different types of particles are shown by the current changes extracted from the transfer curves.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!