The effects of intramuscular administration of neostigmine and physostigmine on Na,K-ATPase activity in various cerebral subdivisions were examined in rats. In CNS and peripheral tissues, both agents rapidly and significantly reduced activity of cholinesterases by 30-50%. The development of intoxication did not change the marker indices of stress reaction. In the cerebral cortex, physostigmine increased Na,K-ATPase activity, whereas neostigmine suppressed it. In addition, neostigmine decreased activity of this enzyme in the cerebellum. In contrast, both agents produced no effects on Na,K-ATPase activity in the striatum. The data corroborate the view on functional interaction between Na,K-ATPase and nicotinic cholinoreceptors in rat cerebral cortex.
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