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| http://dx.doi.org/10.1016/j.ekir.2018.07.014 | DOI Listing |
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Unravelling a mystery of hypokalemic hypertension- a rare case report of a reninoma.
BMC Endocr Disord
December 2024
National Hospital of Sri Lanka, Colombo, Sri Lanka.
Background: Reninoma is a rare cause of secondary hypertension, which can be cured with surgery if identified early before any target organ damage occurs. It leads to hypokalaemia and hypertension and typically responds well to treatment with renin-angiotensin-aldosterone system blockers. However, confirmation of the diagnosis and the localisation of this rare culprit lesion can be challenging.
View Article and Find Full Text PDFReninoma: an unusual cause of growth failure.
J Pediatr Endocrinol Metab
January 2025
Department of Endocrinology and Diabetes, Max Super Speciality Hospital, Saket, Delhi, India.
Objectives: Growth failure can result from various underlying causes, necessitating a thorough evaluation. Reninoma, a rare renin-secreting tumor, is an uncommon cause of hypertension, especially in paediatric patients, and has not been associated with growth failure until now.
Case Presentation: An 11-year-old girl presented with complaints of poor height gain, headaches, increased thirst, and vomiting.
Background: If C is creatinine clearance, a surrogate for glomerular filtration rate (GFR), the serum potassium concentration (K) is the sum of E/C and TR/C, which are amounts of potassium excreted and (net) reabsorbed per volume of filtrate (K = E/C + TR/C). We investigated changes in E/C, TR/C, and K through the stages of chronic kidney disease (CKD).
Materials And Methods: We performed a retrospective study of 452 patients with CKD stages G1 - 5.
Sjögren's syndrome complicated with hypothyroidism and osteomalacia: A case report.
Medicine (Baltimore)
September 2024
Department of Endocrinology, Shenzhen Longhua District Central Hospital, Shenzhen, Guangdong, China.
Article Synopsis
- Sjögren syndrome (SS) is a common autoimmune disorder primarily affecting exocrine glands, leading to symptoms like dry eyes and mouth, but often goes undiagnosed.
- A 22-year-old female exhibited uncommon symptoms such as hypokalemic paralysis and severe bone pain, prompting an extensive diagnostic evaluation.
- After confirming distal renal tubular acidosis as a complication of SS, the patient received targeted treatment, resulting in significant improvement within two weeks, highlighting the need for awareness and prompt treatment of SS in younger patients.
Genetic background of neonatal hypokalemia.
Pediatr Nephrol
February 2025
Guangzhou Women and Children's Medical Center, National Children's Medical Center for South Central Region, Guangzhou Medical University, 9 Jinsui Road, Guangzhou, China.
Article Synopsis
- * The review highlights two main genetic mechanisms: increased potassium loss due to renal abnormalities and decreased potassium availability from ion channel defects, affecting multiple organs like kidneys, intestines, and muscles.
- * It details over ten genetic disorders linked to hypokalemia, emphasizing specific genes (e.g., SLC12A1 for Bartter syndrome and SLC26A3 for congenital chloride diarrhea) that illustrate the complexity of this condition and its clinical implications.
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