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Injecting hope: the potential of intratumoral immunotherapy for locally advanced and metastatic cancer.
Front Immunol
January 2025
BIOCEV, First Faculty of Medicine, Charles University, Vestec, Czechia.
Despite enormous progress, advanced cancers are still one of the most serious medical problems in current society. Although various agents and therapeutic strategies with anticancer activity are known and used, they often fail to achieve satisfactory long-term patient outcomes and survival. Recently, immunotherapy has shown success in patients by harnessing important interactions between the immune system and cancer.
View Article and Find Full Text PDFAntioxidant therapy for infertile couples: a comprehensive review of the current status and consideration of future prospects.
Front Endocrinol (Lausanne)
January 2025
Department of Obstetrics and Gynaecology, Assiut University, Assiut, Egypt.
Oxidative stress (OS) is established as a key factor in the etiology of both male and female infertility, arising from an imbalance between reactive oxygen species (ROS) production and the endogenous antioxidant (AOX) defenses. In men, OS adversely affects sperm function by inducing DNA damage, reducing motility, significantly impairing sperm vitality through plasma membrane peroxidation and loss of membrane integrity, and ultimately compromising overall sperm quality. In women, OS is implicated in various reproductive disorders, including polycystic ovary syndrome, endometriosis, and premature ovarian failure, leading to diminished oocyte quality, disrupted folliculogenesis, and poorer reproductive outcomes.
View Article and Find Full Text PDFAssessment of the hip-spine relationship in total hip arthroplasty for childhood hip disorders sequelae.
World J Orthop
January 2025
Department of Orthopaedic Surgery, Chongqing Orthopedic Hospital of Traditional Chinese Medicine, Chongqing 400043, China.
In this article, we comment on the article by Oommen . Oommen provided a comprehensive overview of the management of hip centre restoration in total hip arthroplasty (THA) for childhood hip disorder sequelae. Given the developmental disparity in this population, specific preoperative planning is an essential prerequisite for the success of THA procedures.
View Article and Find Full Text PDFPeptide hormones in plants.
Mol Hortic
January 2025
Institute of Botany, Chinese Academy of Sciences, Beijing, 100093, China.
Peptide hormones are defined as small secreted polypeptide-based intercellular communication signal molecules. Such peptide hormones are encoded by nuclear genes, and often go through proteolytic processing of preproproteins and post-translational modifications. Most peptide hormones are secreted out of the cell to interact with membrane-associated receptors in neighboring cells, and subsequently activate signal transductions, leading to changes in gene expression and cellular responses.
View Article and Find Full Text PDFNeutrophil heterogeneity and plasticity: unveiling the multifaceted roles in health and disease.
MedComm (2020)
February 2025
Neutrophils, the most abundant circulating leukocytes, have long been recognized as key players in innate immunity and inflammation. However, recent discoveries unveil their remarkable heterogeneity and plasticity, challenging the traditional view of neutrophils as a homogeneous population with a limited functional repertoire. Advances in single-cell technologies and functional assays have revealed distinct neutrophil subsets with diverse phenotypes and functions and their ability to adapt to microenvironmental cues.
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