Bioactive xanthoquinodins and epipolythiodioxopiperazines from 7s-1, an endophytic fungus isolated from (Lour.) Mart.

A new xanthoquinodin B9 (), together with two known xanthoquinodins, xanthoquinodin A1 () and xanthoquinodin A3 (), three epipolythiodioxopiperazines, chetomin (), chaetocochin C () and dethio-tetra(methylthio)chetomin (), and four other compounds, chrysophanol (), emodin (), alatinone (), and ergosterol () were isolated from the endophytic fungus 7s-1, isolated from (Lour.) Mart. All isolated structures were established based on their spectroscopic data analyses. Compounds showed antibacterial activity against Gram positive bacteria with MICs ranging from 0.02 pM to 10.81 µM. Compounds also exhibited cytotoxicity against KB, MCF-7 and NCI-H187 cancer cell lines (IC 0.04-18.40 µM). However, they were cytotoxic towards a normal cell line ( cell) with IC values ranging from 0.04 to 3.86 µM.