FLOTILLIN-1 and FLOTILLIN-2 are membrane rafts associated proteins that have been implicated in insulin and growth factor signaling, endocytosis, cell migration, proliferation, differentiation, cytoskeleton remodeling and membrane trafficking. Furthermore, FLOTILLINs also play important roles in the progression of cancer and neurodegenerative diseases. In this study, the roles of flotillins are investigated in planarian Dugesia japonica. The results show that Djflotillin-1 and Djflotillin-2 play a key role in homeostasis maintenance and regeneration process by regulating the proliferation of the neoblast cells, they are not involved in the maintenance and regeneration of the central nervous system in planarians.
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| http://dx.doi.org/10.1016/j.yexcr.2018.11.009 | DOI Listing |
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Article Synopsis
- The SoxB family of genes is important for how animals work, but scientists don't know much about them in planarians, which are flatworms that can regenerate.
- This study looks at how specific SoxB genes (DjSoxB1, DjSoxB2, and DjSoxB3) help planarians grow back body parts after injury.
- It finds that when these genes are silenced, planarians grow slower and have trouble moving, showing that these genes are crucial for cell growth and normal nerve function during regeneration.
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