With the rising incidence of chronic kidney disease, there has been a steady growth of the hemodialysis (HD) and peritoneal dialysis (PD) population. Prevalence of obesity has also been on the rise. It has been proposed by some that obesity helps with survival in HD and possibly in PD patients-a concept called "Reverse Epidemiology." Here, we attempt to explore this phenomenon in the HD and PD populations and see specifically if it is time to reverse this concept. A MEDLINE search was performed using search terms: obesity, body mass index, end-stage renal disease, HD, PD, renal dialysis, mortality, survival, and reverse epidemiology. Review of recent literature questions the benefit of obesity on survival in the dialysis population-more specifically in PD. Patients on PD with higher muscle mass seem to have the best survival. There should be more focus on malnutrition among such patients.
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http://dx.doi.org/10.1053/j.jrn.2018.09.005 | DOI Listing |
NAR Genom Bioinform
March 2025
Division of Health Medical Intelligence, Human Genome Center, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.
Metagenotyping of metagenomic data has recently attracted increasing attention as it resolves intraspecies diversity by identifying single nucleotide variants. Furthermore, gene copy number analysis within species provides a deeper understanding of metabolic functions in microbial communities. However, a platform for examining metagenotyping results based on relevant grouping data is lacking.
View Article and Find Full Text PDFCureus
December 2024
Internal Medicine, Eastern Virginia Medical School, Norfolk, USA.
Metronidazole is a broad-spectrum antimicrobial that is associated with 0.16% 100-day incidence rates for peripheral neuropathy. In this report, we present an interesting and rare presentation of peripheral neuropathy secondary to metronidazole use for bacteremia and sepsis in a patient with end-stage renal failure.
View Article and Find Full Text PDFBMC Nephrol
January 2025
Department of Internal Medicine, Levanger Hospital, Nord-Trøndelag Health Trust, Levanger, Norway.
Background: Accurate assessment of fluid volume and hydration status is essential in many disease states, including patients with chronic kidney disease. The aim of this study was to investigate the ability of a wearable continuous bioimpedance sensor to detect changes in fluid volume in patients undergoing regular hemodialysis (HD).
Methods: 31 patients with end-stage renal disease were enrolled and monitored with a sensor patch (Re:Balans) on the upper back through two consecutive HD sessions and the interdialytic period between.
AIDS Behav
January 2025
College of Nursing, Florida State University, Knoxville, USA.
While people with HIV (PWH) experience high rates of end-stage kidney disease (ESKD), they were historically denied kidney transplantation and prohibited from organ donation, both elements of treating ESKD. It remains unknown to what extent such HIV criminalization laws correlate with the provision of transplantation education to PWH. We conducted this study to elucidate the relationship between these structural-level policies and individual-level outcomes.
View Article and Find Full Text PDFLife Sci
January 2025
School of Exercise and Health and Shanghai Frontiers Science Research Base of Exercise and Metabolic Health, Shanghai University of Sport, Shanghai 200438, PR China. Electronic address:
Diabetic nephropathy (DN) is one of the most common microvascular complications of diabetes mellitus, characterized by progressive deterioration of renal structure and function, which may eventually lead to end-stage kidney disease (ESKD). The N6-methyladenosine (m6A) methylation, an important modality of RNA modification, involves three classes of key regulators, writers (e.g.
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