AI Article Synopsis
- * Recent research indicates a link between drug resistance and the invasive capabilities of tumor cells.
- * The study highlights the importance of proteins like CD147, CD44, ANAX2, P-gp, MMPs, and UCH-L1 in cancer treatment, suggesting that analyzing these proteins could lead to more effective chemotherapy strategies.
Article Abstract
The main obstacles that lead to clinical failure in cancer treatment are the development of resistant to chemotherapy and a rise in invasive characteristics in cancer tumor cells due to prolonged chemotherapeutic processes. Recent studies have revealed some evidence about the existence of a direct relationship between development of drug resistance and triggering of invasive capability in tumor cells. Therefore, devising and application of chemotherapeutic procedures that are not prone to the development of chemotherapy resistance are necessary. Here, we focus on CD147, CD44, ANAX2, P-gp, MMPs, and UCH-L1 proteins involved in the crosstalk between metastasis and cancer treatment. We think that further structural and functional analysis of these proteins may direct scientists towards designing highly effective chemotherapy procedures.
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| http://dx.doi.org/10.1016/j.critrevonc.2018.09.017 | DOI Listing |
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