AI Article Synopsis
- * Researchers combined a 2,4-diaminopyrimidine structure with the tetrahydrocarbazole to make new hybrid compounds, which were also evaluated for antibacterial activity.
- * The most effective hybrid compound, identified as 12c, displayed strong antibacterial effects with low minimum inhibitory concentration (MIC) values against both S. aureus Newman and E. coli AB1157, as well as against multiple drug-resistant S. aureus strains.
Article Abstract
Several 6-substituted tetrahydrocarbazole derivatives were designed, synthesized and evaluated for the antibacterial activities against Staphylococcus aureus Newman strain. Subsequently, 2,4-diaminopyrimidine scaffold was merged with the tetrahydrocarbazole unit to generate a series of novel hybrid derivatives and the antibacterial activities were also investigated. Among these novel hybrids, compound 12c showed the most potent activity with a MIC of 0.39-0.78 μg/mL against S. aureus Newman and Escherichia coli AB1157 strain. In addition, compound 12c exhibited low MIC values against a panel of multidrug-resistant strains of S. aureus.
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| http://dx.doi.org/10.1016/j.ejmech.2018.11.016 | DOI Listing |
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