Premalignant and malignant oral mucosal lesions: Clinical and pathological findings.

J Am Acad Dermatol

Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts; US Department of Veteran Affairs, Boston Health Care System, Boston, Massachusetts. Electronic address:

Published: July 2019

AI Article Synopsis

  • The article focuses on identifying clinical and histopathologic characteristics of common premalignant and malignant oral lesions, emphasizing their significance in diagnosis.
  • It highlights the role of dermatologists in recognizing suspicious lesions and making decisions about biopsies, patient counseling, and referrals.
  • The piece underscores the importance of early diagnosis and multidisciplinary treatment approaches to improve survival rates for patients with oral cavity cancers.

Article Abstract

The second article in this continuing medical education series discusses the clinical and histopathologic features of common premalignant and malignant lesions of the oral cavity. It is imperative for dermatologists to be able to appropriately recognize suspicious lesions, determine the need to obtain a biopsy specimen, counsel, and refer patients presenting with premalignant or malignant conditions. Given the higher rates of mortality and morbidity of oral mucosal malignancies because of late diagnosis, appropriate treatment with multidisciplinary care in a timely manner is essential to patients with these neoplasms.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaad.2018.09.060DOI Listing

Publication Analysis

Top Keywords

premalignant malignant
12
oral mucosal
8
malignant oral
4
mucosal lesions
4
lesions clinical
4
clinical pathological
4
pathological findings
4
findings second
4
second article
4
article continuing
4

Similar Publications

Introduction: Hematopoietic stem cell transplantation is a potentially curative intervention for a broad range of diseases. However, there is evidence that malignant or pre-malignant clones contained in the transplant can expand in the recipient and trigger donor-derived malignancies. This observation has gained much attention in the context of clonal hematopoiesis, a medical condition where significant amounts of healthy blood cells are derived from a small number of hematopoietic stem cell clones.

View Article and Find Full Text PDF

Background: Cervical cancer is a common cancer worldwide, with > 85% of deaths occurring in Lower- and Middle-Income Countries where resources for screening programs are limited. Women living with HIV (WLHIV) are at increased risk. HPV test-and-treat is a screening strategy where women with HPV are offered ablative treatment of the cervix to reduce the risk of invasive cancer.

View Article and Find Full Text PDF

E-Cigarette Effects on Oral Health: A Molecular Perspective.

Food Chem Toxicol

December 2024

Departments of Otolaryngology-Head and Neck Surgery; Departments of Cell Biology, The University of Oklahoma Health Sciences Center, Oklahoma City OK 73104, USA; Departments of TSET Health Promotion Research Center, Stephenson Cancer Center, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA. Electronic address:

Electronic cigarettes (e-cigarettes) have emerged as a potential alternative to traditional smoking and may aid in tobacco harm reduction and smoking cessation. E-cigarette use has notably increased, especially among young non-tobacco users, raising concerns due to the unknown long-term health effects. The oral cavity is the first and one of the most crucial anatomical sites for the deposition of e-cigarette aerosols.

View Article and Find Full Text PDF

P53 and Ki67 Biomarkers are Predictors for Malignant Transformation in Oral Submucous Fibrosis: A Prospective Study.

Asian Pac J Cancer Prev

December 2024

Department of Periodontology, HKDET'S Dental College, Hospital and Reaserch Institute, Humnadad, Karnataka, India.

Objectives: Oral submucous fibrosis (OSMF) is a potentially malignant disorder (PMD) characterized by a high rate of malignant transformation (MT). OSMF exhibits atrophic epithelium yet has a high proliferation rate. Both p53 and Ki67 are nuclear proteins associated with cell proliferation, detectable in the early stages of oral cancer (OC).

View Article and Find Full Text PDF

Background: This study aimed to investigate the potential utility of Epithelial-mesenchymal transition (EMT) signaling cell detection in the early diagnosis of cervical lesions.

Methods: Enrichment of cervical epithelial cells was carried out using a calibrated membrane with 8-μm diameter pores. RNA-in situ hybridization (RNA-ISH) was employed to detect and characterize EMT cells utilizing specific EMT markers.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!