Geroprotectors are compounds that slow the rate of biological aging and therefore may reduce the incidence of age-associated diseases such as Alzheimer's disease (AD). However, few have therapeutic efficacy in mammalian AD models. Here we describe the identification of geroneuroprotectors (GNPs), novel AD drug candidates that meet the criteria for geroprotectors.
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| http://dx.doi.org/10.1016/j.tips.2018.09.008 | DOI Listing |
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Geroneuroprotectors: Effective Geroprotectors for the Brain.
Trends Pharmacol Sci
December 2018
Cellular Neurobiology Laboratory CNB-S, Salk Institute, La Jolla, CA 92037-1002, USA. Electronic address:
Geroprotectors are compounds that slow the rate of biological aging and therefore may reduce the incidence of age-associated diseases such as Alzheimer's disease (AD). However, few have therapeutic efficacy in mammalian AD models. Here we describe the identification of geroneuroprotectors (GNPs), novel AD drug candidates that meet the criteria for geroprotectors.
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