A new ester () and a terpenoid () were isolated from the dried whole plant of (H) E. ex D for the first time and their structures were elucidated, as well as their biological activities are described. The two compounds all showed good antifungal activities, especially furanone () exhibited better antifungal activity against and with EC value of 22.82, 18.90 g/mL, respectively. Compound exhibited a significant promotion on the neurite outgrowth in NGF-induced PC-12 cells, and moderate inhibition on the NO production induced by lipopolysaccharide (LPS) in BV-2 microglial cells.
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http://dx.doi.org/10.1080/14786419.2018.1519709 | DOI Listing |
Nat Prod Res
June 2020
College of Chemistry & Pharmacy, Shaanxi Key Laboratory of Natural Products & Chemical Biology, Northwest A&F University, Yangling, P. R. China.
A new ester () and a terpenoid () were isolated from the dried whole plant of (H) E. ex D for the first time and their structures were elucidated, as well as their biological activities are described. The two compounds all showed good antifungal activities, especially furanone () exhibited better antifungal activity against and with EC value of 22.
View Article and Find Full Text PDFStreptomycetes are widely distributed in the marine environment, although only a few studies on their associations to algae and coral ecosystems have been reported. Using a culture-dependent approach, we have isolated antibiotic-active Streptomyces species associated to diverse intertidal marine macroalgae (Phyllum Heterokontophyta, Rhodophyta, and Chlorophyta), from the central Cantabrian Sea. Two strains, with diverse antibiotic and cytotoxic activities, were found to inhabit these coastal environments, being widespread and persistent over a 3-year observation time frame.
View Article and Find Full Text PDFMini Rev Med Chem
February 2013
Laboratorio de Investigacion de Productos Naturales, Escuela Superior de Ingenieria Quimica e Industrias extractivas IPN. Av. Instituto Politecnico Nacional, Unidad Profesional Adolfo Lopez Mateos cp 07758, Mexico D.F.
Objective: Piper has been used for long timelike condiment and food, but also in traditional medicine around of the world. This work resumes the available and up to date work done on members of the Piperaceae family and their uses for therapeutic purposes.
Methods: Information on Piper genus was gathered via internet using scientific databases such as Scirus, Google Scholar, CAB-abstracts, MedlinePlus, Pubmed, SciFinder, Scopus and Web of Science.
Boll Chim Farm
September 2001
Department of Technology of Drugs, Wroclaw University of Medicine, Wroclaw, Poland.
The authors present examples of polycyclic 4(3H)-quinazolinones of natural origin. Structures and syntheses of pharmacologically active (antibacterial, antifungal, antihypertensive and cardiovascular, antiasthmatic, anti-inflamatory, CNS-depresant, secretion of gastric acid inhibitors) compounds are described.
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