Interactions between gene regulatory networks and metabolism produce a diversity of dynamics, including multistability and oscillations. Here, we characterize a regulatory mechanism that drives the emergence of periodic oscillations in metabolic networks subject to genetic feedback regulation by pathway intermediates. We employ a qualitative formalism based on piecewise linear models to systematically analyze the behavior of gene-regulated metabolic pathways. For a pathway with two metabolites and three enzymes, we prove the existence of two co-existing oscillatory behaviors: damped oscillations towards a fixed point or sustained oscillations along a periodic orbit. We show that this mechanism closely resembles the "metabolator", a genetic-metabolic circuit engineered to produce autonomous oscillations in vivo.
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| http://dx.doi.org/10.1016/j.jtbi.2018.10.026 | DOI Listing |
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