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A Critical Reappraisal of Haloperidol for Delirium Management in the Intensive Care Unit: Perspective from Psychiatry.
J Clin Med
January 2025
Department of Psychiatry and Behavioral Sciences, School of Medicine, Stanford University, Stanford, CA 94305, USA.
Delirium is a complex neuropsychiatric syndrome with multifactorial pathophysiology, encompassing a wide range of neuropsychiatric symptoms, and its management remains a significant challenge in critical care. Although often managed with antipsychotics, like haloperidol, current research has predominantly focused on dopamine dysregulation as the primary driver of delirium, overlooking its broader neuroanatomical and neurochemical underpinnings. This has led to a majority of research focusing on haloperidol as a treatment for intensive care unit (ICU) delirium.
View Article and Find Full Text PDFPrevalence of delirium in German nursing homes: protocol for a cross-sectional study.
BMJ Open
January 2025
German Centre for Neurodegenerative Diseases (DZNE), Witten, Nordrhein-Westfalen, Germany
Introduction: Delirium is a neuropathological syndrome that is associated with several negative outcomes. Nursing home residents are vulnerable to developing delirium. Valid prevalence data and associated factors are not yet available for Germany.
View Article and Find Full Text PDFGlobal prevalence and risk factors of delirium among patients following acute stroke: A systematic review and meta-analysis.
J Stroke Cerebrovasc Dis
January 2025
School of Nursing, Taipei Medical University, Taipei, Taiwan; Department of Nursing, Taipei Medical University Hospital; Research Center of Sleep Medicine, Taipei Medical University Hospital; Research Center of Sleep Medicine, College of Medicine, Taipei Medical University.
Background And Objective: The exact prevalence and risk factors of delirium following stroke at an acute stage remains unclear. We aimed to determine the global prevalence and risk factors of delirium following acute stroke.
Method: Observational studies reporting the prevalence of or risk factors for delirium following acute stroke published in the PubMed, Embase, and Scopus databases before April 16, 2024, were identified.
Subtypes of brain change in aging and their associations with cognition and Alzheimer's disease biomarkers.
Neurobiol Aging
December 2024
Center for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo 0373, Norway.
Structural brain changes underlie cognitive changes and interindividual variability in cognition in older age. By using structural MRI data-driven clustering, we aimed to identify subgroups of cognitively unimpaired older adults based on brain change patterns and assess how changes in cortical thickness, surface area, and subcortical volume relate to cognitive change. We tested (1) which brain structural changes predict cognitive change (2) whether these are associated with core cerebrospinal fluid (CSF) Alzheimer's disease biomarkers, and (3) the degree of overlap between clusters derived from different structural modalities in 1899 cognitively healthy older adults followed up to 16 years.
View Article and Find Full Text PDFDelirium Motor Subtypes and Severity of Physical Symptoms in Patients with Advanced Cancer in Inpatient Hospice/Palliative Care Units: A Multicenter Prospective Cohort Study.
J Palliat Med
December 2024
Palliative and Supportive Care Division, Seirei Mikatahara General Hospital, Hamamatsu, Japan.
Article Synopsis
- Delirium alters cognitive function and may impact the severity of physical symptoms like pain and dyspnea in palliative care patients, but the specific effects of different motor subtypes of delirium are not fully understood.
- A study analyzed patient data from 23 hospices in Japan, focusing on advanced cancer patients who experienced delirium and its motor subtypes at the time of admission and later on.
- Results indicated that patients with hyperactive or mixed delirium had significantly higher odds of experiencing severe pain and dyspnea compared to those without delirium, while hypoactive delirium did not show a similar association.
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