Ligneous conjunctivitis is a rare and poorly understood pathology. Infections and repeated microtraumas are often involved in acute disease flare-ups. This masquerade may lead to misdiagnosis and delayed treatment. We report two cases of ligneous conjunctivitis, describing various presentations of its natural history and focusing on the treatment of this rare disease.
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http://dx.doi.org/10.1016/j.jfo.2018.03.012 | DOI Listing |
Orbit
November 2024
Corneoplastic Unit, Queen Victoria Hospital NHS Foundation Trust, East Grinstead, UK.
Spec Care Dentist
December 2024
Department of Pathology and Oral Diagnosis, School of Dentistry, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
SAGE Open Med Case Rep
July 2024
Department of Neurosurgery, Istishari Arab Hospital, Ramallah, Palestine.
Type I plasminogen (PLG I) deficiency is a genetic disorder inherited in an autosomal recessive mode and carries high mortality and morbidity. This case report discusses two babies, aged 2 and 3 months, who were diagnosed with ligneous conjunctivitis and congenital hydrocephalus. They had progressive macrocephaly, which led to the insertion of a ventriculoperitoneal shunt.
View Article and Find Full Text PDFFront Cardiovasc Med
June 2024
Department of Chemistry and Biochemistry and the W.M. Keck Center for Transgene Research, University of Notre Dame, Notre Dame, IN, United States.
Human plasminogen (PLG), the zymogen of the fibrinolytic protease, plasmin, is a polymorphic protein with two widely distributed codominant alleles, PLG/Asp and PLG/Asn. About 15 other missense or non-synonymous single nucleotide polymorphisms (nsSNPs) of PLG show major, yet different, relative abundances in world populations. Although the existence of these relatively abundant allelic variants is generally acknowledged, they are often overlooked or assumed to be non-pathogenic.
View Article and Find Full Text PDFAdv Skin Wound Care
July 2024
Robert Wayne Decker, MD, is Clinical Assistant Professor of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA. Joseph Mickler Parker, MD, is Consultant to Kedrion Biopharma Inc, Fort Lee, New Jersey. Jeremy Lorber, MD, is Assistant Clinical Professor, Cedars-Sinai Medical Center. Roberto Crea, DVM, is Medical Affairs Director, Kedrion S.p.A, Barga, Italy. Karen Thibaudeau, PhD, is Medical Affairs Director, Prometic Bioproduction, Laval, Quebec, Canada.
Intravenous plasminogen replacement therapy for patients with plasminogen deficiency type 1 (hypoplasminogenemia) was recently approved for marketing in the US. In this case report, the authors describe a 33-year-old man with hypoplasminogenemia who developed nonhealing postsurgical wounds following trauma to his right hand despite receiving standard treatment for 4 months. The patient was enrolled in a compassionate-use protocol with intravenous plasminogen replacement therapy and experienced prompt resolution of surgical wounds.
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