Atrial Fibrillation (AFib) is by itself a strong risk factor for many life-threatening heart diseases. An estimated 2.7 to 6.1 million people in the United States have AFib. With the aging of the U.S. population, this number is expected to increase. In this preliminary study, a heart rate-duration criteria region is proposed to automatically label symptomatic AFib events using recordings from portable ECG monitors. A Markov Chain algorithm is implemented to classify prediction intervals that are 2 minutes before the symptomatic AFib events. The method yields an overall accuracy value of 82% with 0.91 AUC.
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http://dx.doi.org/10.1109/EMBC.2018.8513006 | DOI Listing |
ACG Case Rep J
March 2025
Department of Medicine, Division of Gastroenterology & Hepatology, Barnes-Jewish Hospital/Washington University in St. Louis, St. Louis, MO.
Esophageal thermal injury from atrial fibrillation ablation is not uncommon; however, full-thickness perforation is rare. Such injuries are often treated with surgical revision, stent placement, or medical management. Endoscopic vacuum therapy is a novel and emerging technique to repair transmural gastrointestinal defects; however, its use in the management of esophageal thermal ulceration and perforation after a cardiac ablation procedure is limited.
View Article and Find Full Text PDFFront Cardiovasc Med
February 2025
Department of Cardiology, The Fifth Affiliated Hospital of Guangxi Medical University, Nanning, China.
Research Objective: This study is based on bioinformatics analysis to explore the co-expressed differentially expressed genes (DEGs) between atrial fibrillation (AF) and chronic kidney disease (CKD), identify the biomarkers for the occurrence and development of the two diseases, investigate the potential connections between AF and CKD, and explore the associations with immune cells.
Methods: We downloaded Two AF gene chip datasets (GSE79768, GSE14975) and two CKD gene chip datasets (GSE37171, GSE120683) from the GEO database. After pre-processing and standardizing the datasets, two DEGs datasets were obtained.
Background: The mechanism by which ibrutinib, a Bruton's tyrosine kinase inhibitor, can elevate the risk of arrhythmias is not fully elucidated. In this study, we explored how inhibition of off-target kinases can contribute to this phenomenon.
Methods: We performed a Mendelian randomization analysis to examine the causal associations between genetically proxied inhibition of six putative ibrutinib drug targets (ErbB2/HER2, CSK, JAK3, TEC, BLK, and PLCG2) and the atrial fibrillation (AF) risk, proarrhythmic ECG indices, and cardiometabolic traits and diseases.
J Cardiovasc Electrophysiol
March 2025
Department of Medicine, Cardiac Electrophysiology Program, Division of Cardiovascular Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Phrenic nerve injury, though rare, can be a serious complication of catheter ablation leading to significant morbidity. The close proximity of the phrenic nerve to the site of origin of arrhythmias may also impact the success of catheter ablation. When the phrenic nerve is near the optimal site of ablation, several techniques have been proposed to create separation between the nerve and the epicardium, including the introduction of fluid, gas, and balloons.
View Article and Find Full Text PDFNutrients
March 2025
Allelica Inc., San Francisco, CA 94105, USA.
Background: Polygenic risk score (PRS) quantifies the cumulative effects of common genetic variants across the genome, including both coding and non-coding regions, to predict the risk of developing common diseases. In cardiovascular medicine, PRS enhances risk stratification beyond traditional clinical risk factors, offering a precision medicine approach to coronary artery disease (CAD) prevention. This study evaluates the predictive performance of a multi-ancestry PRS framework for cardiovascular risk assessment using the All of Us (AoU) short-read whole-genome sequencing dataset comprising over 225,000 participants.
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