This paper presents the design and fabrication of an implantable control unit intended for epidural spinal cord stimulation (ESCS) in rats. The device offers full programmability over stimulation parameters and delivers a constant current to an electrode array to be located within the spinal canal. It implements an adaptive voltage compliance in order to reduce the unnecessary power dissipation often experienced in current-controlled stimulation (CCS) devices. The compliance is provided by an adjustable boost converter that offers a voltage output in the range of 6.24 V to 28 V, allowing the device to deliver currents up to 1 mA through loads up to $25 \mathrm {k}\Omega $. The system has been fabricated using discrete components, paving the way to an inexpensive product that can easily be manufactured and batch produced. The control unit occupies a total volume of ~13.5 cm and therefore fulfills the size restrictions of a system to be implanted in a rat. Results indicate that by adjusting the voltage compliance a total power efficiency up to 35.5% can be achieved, saving around 60 mW when using lower stimulation currents or operating on smaller impedances. The achieved efficiency is the highest compared to similar stateof-the-art systems.
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http://dx.doi.org/10.1109/EMBC.2018.8512904 | DOI Listing |
Cureus
January 2025
Neurology, Adventist Health White Memorial, Los Angeles, USA.
A subset of amyotrophic lateral sclerosis (ALS) patients tests positive for antibodies commonly associated with autoimmune neurological diseases, including voltage-gated potassium channel (VGKC)-complex antibodies. Although an autoimmune basis for ALS remains speculative, and immunomodulatory therapies have shown minimal benefit as of yet, isolated cases suggest that VGKC-complex antibodies may be relevant to disease type and progression. In this report, we present a case of ALS in which increasing VGKC-complex antibody levels correlated with clinical decline, raising the question of whether such antibodies could serve as biomarkers of progression in VGKC-complex antibody-positive ALS patients.
View Article and Find Full Text PDFSensors (Basel)
December 2024
Centre de Recherche et de Restauration des Musées de France (C2RMF), 75008 Paris, France.
Heavy metal pollution, particularly from cadmium (Cd) and copper (Cu), poses significant environmental and health risks. To address the need for efficient, portable, and sensitive detection methods, this study introduces an improved atmospheric pressure glow discharge atomic emission spectrometry (APGD-AES) technique for quantifying Cd and Cu in water samples. The APGD-AES method offers key advantages, including low energy consumption (<33 W), high excitation energy, and compact design.
View Article and Find Full Text PDFSensors (Basel)
November 2024
Research Unit of Electronics for Sensor Systems, Department of Engineering, University Campus Bio-Medico di Roma, 00128 Rome, Italy.
Electrical stimulation can be used in several applications such as fatigue reduction, muscle rehabilitation, neurorehabilitation, neuro-prosthesis and pain relief. Moreover, electrical stimulation can be used for drug delivery applications or body fluids extraction (e.g.
View Article and Find Full Text PDFMed Biol Eng Comput
December 2024
Department of Applied Physics III, Universidad de Sevilla, Camino de los Descubrimientos, S/N, 41092, Sevilla, Spain.
Neural electrostimulation has enabled different therapies to treat a number of health problems. For example, the cochlear implant allows for recovering the hearing function and deep brain electrostimulation has been proved to reduce tremor in Parkinson's disease. Other approaches such as retinal prostheses are progressing rapidly, as researchers continue to investigate new strategies to activate targeted neurons more precisely.
View Article and Find Full Text PDFHeliyon
October 2024
Department of Computers and Information Technologies, College of Sciences and Arts Turaif, Northern Border University, Arar 91431, Saudi Arabia.
The Environmental Economic Power Dispatch (EEPD) problem, a widely studied bi-objective nonlinear optimization challenge in power systems, traditionally focuses on the economic dispatch of thermal generators without considering network security constraints. However, environmental sustainability necessitates reducing emissions and increasing the penetration of renewable energy sources (RES) into the electrical grid. The integration of high levels of RES, such as wind and solar PV, introduces stability issues due to their uncertain and intermittent nature.
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