Injuries, accidents, strokes, and other diseases can significantly degrade the capabilities to perform even the most simple activities in daily life. While assistive technology becomes more and more available to the people affected, there is still a big need for user interfaces suitable for people without functional hand movement. A large share of these cases involves neuromuscular diseases, which lead to severely reduced muscle function. However, even though affected people are no longer able to functionally move their limbs, residual muscle function can still be existent. Previous work has shown that this residual muscular activity can suffice, to create an EMG-based user interface, and e.g., allow for control of assistive devices. In this paper, we enhance this user interface with additional EMG-features and an improved training paradigm in order to increase information extraction from recordings of strongly atrophic muscles. The interface was tested and validated by subjects with severe spinal muscular atrophy. Results show that the used methods improve the decoding and thereby allow for a considerable increase in performance when controlling a robotic manipulator in a 3D reaching task.
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http://dx.doi.org/10.1109/EMBC.2018.8512689 | DOI Listing |
Disabil Rehabil Assist Technol
March 2025
Faculty of Physiotherapy and Nursing. Department of Nursing, Physiotherapy and Occupational Therapy, Universidad de Castilla-La Mancha, Toledo, Spain.
Purpose: To describe the experiences of parents who used powered mobility in children with Spinal Muscular Atrophy, SMA type I,at an early age in the natural context like a family-centered program, using inductive qualitative content analysis.
Materials And Methods: This qualitative study was embedded within a single-blinded randomized waiting list controlled clinical trial, which involved 16 children with SMA type I. This study specifically explores the experiences of the 9 parents whose children participated in the intervention group and completed the training.
Cells
February 2025
Faculty of Sport Sciences, Waseda University, Tokorozawa 359-1192, Japan.
Background: Skeletal muscle wasting is commonly observed in aging, immobility, and chronic diseases. In pathological conditions, the impairment of skeletal muscle and immune system often occurs simultaneously. Recent studies have highlighted the initiative role of skeletal muscle in interactions with immune cells.
View Article and Find Full Text PDFAnn Acad Med Singap
February 2025
Graduate Institute of Medicine, Yuan Ze University, Taoyuan, Taiwan.
Introduction: The diagnosis of sarcopenia relies on key indicators such as handgrip strength, walking speed and muscle mass. Developing a composite index that integrates these measures could enhance clinical evaluation in older adults. This study aimed to standardise and combine these metrics to establish a z score for the sarcopenia composite index (ZoSCI) tailored for the ageing population.
View Article and Find Full Text PDFJ Transl Med
March 2025
International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, 910 Hengshan Road, Shanghai, 200030, China.
Background: Next-generation sequencing (NGS) has been applied for carrier screening, effectively reducing the incidence of severe diseases. However, some severe, high-prevalent and complex diseases, including spinal muscular atrophy (SMA), α-/β-thalassemia, 21-hydroxylase deficiency (21-OHD), and fragile-X syndrome (FXS), cannot be fully addressed by NGS, resulting in a high residual risk ratio. This study aims to evaluate the clinical utility of a long-read sequencing (LRS) panel for carrier screening of these five complex diseases.
View Article and Find Full Text PDFSyst Rev
March 2025
Department of Respiratory and Critical Care Medicine, the First College of Clinical Medicine Science, Chinaaq , Three Gorges University, Yichang, 443003, People's Republic of China.
Background: COPD patients suffering from malnutrition or sarcopenia often incur higher healthcare costs and experience adverse clinical outcomes. Despite this, the effectiveness of nutrient supplements in this population remains uncertain.
Methods And Analysis: Two reviewers will independently search seven databases-PubMed, Embase, Web of Science, China National Knowledge Infrastructure, Wanfang, Chinese Biomedical Literature Database, and the Cochrane Library-for randomized controlled trials (RCTs) published before August 31, 2024.
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