The use of graphs to analyze cerebrovascular networks is quite common in studies of the microcirculation. While we have learned a lot from studies utilizing graphs as a tool for the analysis of microvessels, most methodologies for these procedures have only been described in brief and most are not publicly accessible. In this work, we introduce the foundation for an anticipated open-source framework that we hope will streamline the analysis of cerebrovascular structure. We believe that a standardized and accessible framework for the analysis vascular filaments is not only needed, but is necessary, for studies charting the microcirculation on image volumes spanning several grains of tissue. We set forth the foundations for a comprehensive and complete framework in our current work.
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